Zhan Dan-Ting, Xian Hong-Chun
Department of Prosthodontics, Affiliated Stomatological Hospital of Southwest Medical University, Luzhou, China.
Department of Plastic and Maxillofacial Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Oncol. 2023 Aug 10;13:1191913. doi: 10.3389/fonc.2023.1191913. eCollection 2023.
Imbalanced immune homeostasis in cancer microenvironment is a hallmark of cancer. Increasing evidence demonstrated that long non-coding RNAs (lncRNAs) have emerged as key regulatory molecules in directly blocking the cancer immunity cycle, apart from activating negative regulatory pathways for restraining tumor immunity. lncRNAs reshape the tumor microenvironment via the recruitment and activation of innate and adaptive lymphoid cells. In this review, we summarized the versatile mechanisms of lncRNAs implicated in cancer immunity cycle, including the inhibition of antitumor T cell activation, blockade of effector T cell recruitment, disruption of T cell homing, recruitment of immunosuppressive cells, and inducing an imbalance between antitumor effector cells (cytotoxic T lymphocytes, M1 macrophages, and T helper type 1 cells) versus immunosuppressive cells (M2 macrophages, T helper type 2 cells, myeloid derived suppressor cells, and regulatory T cells) that infiltrate in the tumor. As such, we would highlight the potential of lncRNAs as novel targets for immunotherapy.
癌症微环境中免疫稳态失衡是癌症的一个标志。越来越多的证据表明，长链非编码RNA（lncRNAs）已成为直接阻断癌症免疫循环的关键调控分子，此外还能激活抑制肿瘤免疫的负调控途径。lncRNAs通过募集和激活先天性和适应性淋巴细胞来重塑肿瘤微环境。在这篇综述中，我们总结了lncRNAs参与癌症免疫循环的多种机制，包括抑制抗肿瘤T细胞活化、阻断效应T细胞募集、破坏T细胞归巢、募集免疫抑制细胞，以及诱导浸润肿瘤的抗肿瘤效应细胞（细胞毒性T淋巴细胞、M1巨噬细胞和1型辅助性T细胞）与免疫抑制细胞（M2巨噬细胞、2型辅助性T细胞、骨髓来源的抑制细胞和调节性T细胞）之间的失衡。因此，我们将强调lncRNAs作为免疫治疗新靶点的潜力。
