形态还是迁移？血流如何塑造不同的血管网络。

Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks.

机构信息

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.

Max-Delbrück Center for Molecular Medicine, 13125 Berlin, Germany; Vascular Patterning Laboratory, Center for Cancer Biology, VIB, Department of Oncology, KU Leuven, 3000 Leuven, Belgium; DZHK (German Centre for Cardiovascular Research), partner site Berlin, 13347 Berlin, Germany; Berlin Institute of Health, 10117 Berlin, Germany.

出版信息

Dev Cell. 2017 Jun 19;41(6):574-576. doi: 10.1016/j.devcel.2017.06.008.

DOI:10.1016/j.devcel.2017.06.008

PMID:28633012

Abstract

Blood vessel shape is malleable and dynamically regulated. In two recent papers in Nature Cell Biology, Jin et al. (2017) and Sugden et al. (2017) show that endoglin alters endothelial cell shape or behavior in response to blood flow, thus regulating vessel structure.

摘要

血管形态具有可塑造性和动态调节性。在最近发表于《自然细胞生物学》的两篇论文中，Jin 等人（2017）和 Sugden 等人（2017）表明，内皮糖蛋白能够响应血流改变内皮细胞的形状或行为，从而调节血管结构。