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形态还是迁移?血流如何塑造不同的血管网络。

Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks.

机构信息

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.

Max-Delbrück Center for Molecular Medicine, 13125 Berlin, Germany; Vascular Patterning Laboratory, Center for Cancer Biology, VIB, Department of Oncology, KU Leuven, 3000 Leuven, Belgium; DZHK (German Centre for Cardiovascular Research), partner site Berlin, 13347 Berlin, Germany; Berlin Institute of Health, 10117 Berlin, Germany.

出版信息

Dev Cell. 2017 Jun 19;41(6):574-576. doi: 10.1016/j.devcel.2017.06.008.

DOI:10.1016/j.devcel.2017.06.008
PMID:28633012
Abstract

Blood vessel shape is malleable and dynamically regulated. In two recent papers in Nature Cell Biology, Jin et al. (2017) and Sugden et al. (2017) show that endoglin alters endothelial cell shape or behavior in response to blood flow, thus regulating vessel structure.

摘要

血管形态具有可塑造性和动态调节性。在最近发表于《自然细胞生物学》的两篇论文中,Jin 等人(2017)和 Sugden 等人(2017)表明,内皮糖蛋白能够响应血流改变内皮细胞的形状或行为,从而调节血管结构。

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Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks.形态还是迁移?血流如何塑造不同的血管网络。
Dev Cell. 2017 Jun 19;41(6):574-576. doi: 10.1016/j.devcel.2017.06.008.
2
Endoglin moves and shapes endothelial cells.内皮糖蛋白使内皮细胞移动和塑形。
Nat Cell Biol. 2017 May 31;19(6):593-595. doi: 10.1038/ncb3543.
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Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.内皮糖蛋白通过内皮细胞形状变化响应血流动力学信号来控制血管直径。
Nat Cell Biol. 2017 Jun;19(6):653-665. doi: 10.1038/ncb3528. Epub 2017 May 22.
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Endothelial cell biology of Endoglin in hereditary hemorrhagic telangiectasia.遗传性出血性毛细血管扩张症中内皮糖蛋白的内皮细胞生物学。
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Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading.内皮糖蛋白通过促进血管平滑肌细胞迁移和铺展来介导血管成熟。
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Endothelial cell mechanics and blood flow forces in vascular morphogenesis.血管发生过程中内皮细胞力学和血流力。
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引用本文的文献

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Mathematical models of developmental vascular remodelling: A review.发育性血管重塑的数学模型:综述。
PLoS Comput Biol. 2023 Aug 3;19(8):e1011130. doi: 10.1371/journal.pcbi.1011130. eCollection 2023 Aug.
2
Remodeling of the Microvasculature: May the Blood Flow Be With You.微血管重塑:愿血流与你同在。
Front Physiol. 2020 Oct 15;11:586852. doi: 10.3389/fphys.2020.586852. eCollection 2020.
3
Endothelial cells and organ function: applications and implications of understanding unique and reciprocal remodelling.
内皮细胞与器官功能:理解独特而相互重塑的应用与意义。
FEBS J. 2020 Mar;287(6):1088-1100. doi: 10.1111/febs.15143. Epub 2019 Dec 4.
4
Current Status of Clinical Diagnosis and Genetic Analysis of Hereditary Hemorrhagic Telangiectasia in South Korea: Multicenter Case Series and a Systematic Review.韩国遗传性出血性毛细血管扩张症的临床诊断与基因分析现状:多中心病例系列研究及系统评价
Neurointervention. 2019 Sep;14(2):91-98. doi: 10.5469/neuroint.2019.00150. Epub 2019 Aug 28.
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Characterization of multi-cellular dynamics of angiogenesis and vascular remodelling by intravital imaging of the wounded mouse cornea.利用活体成像研究小鼠角膜创伤评估血管生成和血管重构的细胞动力学
Sci Rep. 2018 Jul 13;8(1):10672. doi: 10.1038/s41598-018-28770-7.