抑郁症与肺结核风险：一项基于全国人口的队列研究。
Depression and risk of tuberculosis: a nationwide population-based cohort study.
作者信息
Oh K H, Choi H, Kim E J, Kim H J, Cho S I
机构信息
Korean Institute of Tuberculosis, Cheongju, Graduate School of Public Health, Seoul National University, Seoul, Korea.
Korean Institute of Tuberculosis, Cheongju.
出版信息
Int J Tuberc Lung Dis. 2017 Jul 1;21(7):804-809. doi: 10.5588/ijtld.17.0038.
BACKGROUND
Studies on the association between depression and risk of tuberculosis (TB) are lacking.
OBJECTIVE
To determine the association between depression and risk of TB.
METHODS
From a nationwide database, patients with depression were identified to form the exposure cohort between 2003 and 2013. The control cohort comprised an equivalent number of subjects without any mood disorders, with each subject age- and sex-matched to a patient in the exposure cohort. The incidence of TB was identified in the exposure cohort and control cohort between 2003 and 2013. A multivariable Cox proportional hazards model was used to estimate the association between depression and the subsequent risk of TB.
RESULTS
A total of 32 372 patients with depression and the same number of controls were identified. The risk of TB in the depression cohort was 2.63-fold (95%CI 1.74-3.96) higher than in the control cohort. When the depression was classified as 'mild' and 'severe', the risk of TB was proportional to depression severity.
CONCLUSIONS
Patients with depression are at a higher risk for TB, and a dose-response relationship exists between depression and the subsequent risk of TB.
背景
关于抑郁症与结核病（TB）风险之间关联的研究尚缺。
目的
确定抑郁症与结核病风险之间的关联。
方法
从一个全国性数据库中，识别出2003年至2013年间的抑郁症患者以组成暴露队列。对照队列由数量相等的无任何情绪障碍的受试者组成，每个受试者在年龄和性别上与暴露队列中的一名患者匹配。在2003年至2013年间确定暴露队列和对照队列中的结核病发病率。使用多变量Cox比例风险模型来估计抑郁症与后续结核病风险之间的关联。
结果
共识别出32372名抑郁症患者和相同数量的对照。抑郁症队列中的结核病风险比对照队列高2.63倍（95%CI 1.74 - 3.96）。当将抑郁症分为“轻度”和“重度”时，结核病风险与抑郁症严重程度成正比。
结论
抑郁症患者患结核病的风险更高，且抑郁症与后续结核病风险之间存在剂量反应关系。
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