Patel Viral P, Feinstein Anthony
Department of Psychiatry, Sunnybrook Health Sciences Center, Canada.
Mult Scler J Exp Transl Clin. 2017 Jun 8;3(2):2055217317713027. doi: 10.1177/2055217317713027. eCollection 2017 Apr-Jun.
Cognitive function in people with multiple sclerosis (PwMS) is associated with gender differences and the use of smoked/ingested cannabis.
The objective of this report is to explore a possible gender-cannabis interaction associated with cognitive dysfunction in PwMS.
A retrospective analysis was undertaken of cognitive data collected from 140 PwMS. A general linear model was conducted to determine gender and cannabis effects on processing speed (SDMT), verbal (CVLT-II) and visual (BVMT-R) memory, and executive functions (D-KEFS), while controlling for age and years of education.
Cannabis was smoked at least once a month by 33 (23.6%) participants. Cannabis users were more impaired on the SDMT ( = 0.044). Men, who comprised 30.7% of the entire sample and 42.2% of cannabis users, were more impaired on the CVLT-II (total learning, = 0.001; delayed recall, = 0.004). A cannabis-gender interaction was found with the CVLT-II delayed recall ( = 0.049) and BVMT-R total learning ( = 0.014), where male cannabis users performed more poorly than female.
Males with MS may be particularly vulnerable to the cognitive side effects of smoked cannabis use.
多发性硬化症患者（PwMS）的认知功能与性别差异以及吸食/摄入大麻有关。
本报告的目的是探讨PwMS中与认知功能障碍相关的性别-大麻相互作用。
对从140名PwMS收集的认知数据进行回顾性分析。进行一般线性模型以确定性别和大麻对处理速度（SDMT）、言语（CVLT-II）和视觉（BVMT-R）记忆以及执行功能（D-KEFS）的影响，同时控制年龄和受教育年限。
33名（23.6%）参与者每月至少吸食一次大麻。大麻使用者在SDMT上受损更严重（=0.044）。男性占整个样本的30.7%，占大麻使用者的42.2%，在CVLT-II上受损更严重（总学习，=0.001；延迟回忆，=0.004）。在CVLT-II延迟回忆（=0.049）和BVMT-R总学习（=0.014）方面发现了大麻-性别相互作用，男性大麻使用者的表现比女性更差。
患有多发性硬化症的男性可能特别容易受到吸食大麻的认知副作用的影响。
