Kronsteiner Barbara, Bassaganya-Riera Josep, Philipson Casandra, Viladomiu Monica, Carbo Adria, Abedi Vida, Hontecillas Raquel
a Nutritional Immunology and Molecular Medicine Laboratory and Center for Modeling Immunity to Enteric Pathogens; Virginia Bioinformatics Institute; Virginia Tech ; Blacksburg , VA , USA.
b BioTherapeutics ; Blacksburg , VA , USA.
Gut Microbes. 2016;7(1):3-21. doi: 10.1080/19490976.2015.1116673.
Helicobacter pylori is the dominant member of the gastric microbiota in over half of the human population of which 5-15% develop gastritis or gastric malignancies. Immune responses to H. pylori are characterized by mixed T helper cell, cytotoxic T cell and NK cell responses. The presence of Tregs is essential for the control of gastritis and together with regulatory CX3CR1+ mononuclear phagocytes and immune-evasion strategies they enable life-long persistence of H. pylori. This H. pylori-induced regulatory environment might contribute to its cross-protective effect in inflammatory bowel disease and obesity. Here we review host-microbe interactions, the development of pro- and anti-inflammatory immune responses and how the latter contribute to H. pylori's role as beneficial member of the gut microbiota. Furthermore, we present the integration of existing and new data into a computational/mathematical model and its use for the investigation of immunological mechanisms underlying initiation, progression and outcomes of H. pylori infection.
幽门螺杆菌是超过半数人类胃微生物群中的主要成员，其中5%-15%的人会发展为胃炎或胃部恶性肿瘤。对幽门螺杆菌的免疫反应以混合性辅助性T细胞、细胞毒性T细胞和自然杀伤细胞反应为特征。调节性T细胞的存在对于控制胃炎至关重要，它们与调节性CX3CR1+单核吞噬细胞以及免疫逃避策略一起，使幽门螺杆菌能够终生持续存在。这种由幽门螺杆菌诱导的调节环境可能有助于其在炎症性肠病和肥胖症中的交叉保护作用。在这里，我们综述宿主-微生物相互作用、促炎和抗炎免疫反应的发展，以及后者如何促成幽门螺杆菌作为肠道微生物群有益成员的作用。此外，我们将现有数据和新数据整合到一个计算/数学模型中，并将其用于研究幽门螺杆菌感染的起始、进展和结局背后的免疫机制。
