Turk J Med Sci. 2019 Apr 18;49(2):624-634. doi: 10.3906/sag-1810-3.
BACKGROUND/AIM: Erythema nodosum (EN) is an inflammatory disorder of subcutaneous tissue. Although etiopathogenesis of the disease is unknown, many predisposing factors such as infections, systemic disease, and drugs have been identified. Neutrophil to lymphocyte ratio (NLR) has been shown to be a novel inflammatory marker in many dermatological diseases. The aim of our study is to investigate NLR in EN patients and evaluate its relation to the underlying cause of the disease.
Between 2014 and 2018, clinical and laboratory data of 395 patients diagnosed with EN and 395 controls were extracted from patient files. EN patients were grouped as idiopathic EN and secondary EN (EN with an identified underlying cause). Clinical and laboratory characteristics of the two groups were compared
NLR was elevated in EN patients compared to controls (median of 2.38 vs. 1.55, P < 0.001). Among EN patients, NLR was also elevated in patients with secondary EN. In multivariate logistic regression model NLR (> 2.11), RDW-CV (> 13.65), and CRP (> 5.5) were identified as risk factors for secondary EN (relative risks were 17.16, 2.69, and 2, respectively).
Elevated NLR (> 2.11) may be used as a parameter to discriminate secondary EN from idiopathic EN.
背景/目的：结节性红斑（EN）是一种皮下组织的炎症性疾病。尽管其病因不明，但已发现许多诱发因素，如感染、系统性疾病和药物。中性粒细胞与淋巴细胞比值（NLR）已被证明是许多皮肤病的新型炎症标志物。本研究旨在探讨 EN 患者的 NLR，并评估其与疾病潜在病因的关系。
2014 年至 2018 年间，从患者档案中提取了 395 例确诊为 EN 的患者和 395 名对照者的临床和实验室数据。将 EN 患者分为特发性 EN 和继发性 EN（有明确潜在病因的 EN）。比较两组的临床和实验室特征。
与对照组相比，EN 患者的 NLR 升高（中位数 2.38 比 1.55，P < 0.001）。在 EN 患者中，继发性 EN 患者的 NLR 也升高。在多变量逻辑回归模型中，NLR（> 2.11）、RDW-CV（> 13.65）和 CRP（> 5.5）被确定为继发性 EN 的危险因素（相对风险分别为 17.16、2.69 和 2）。
升高的 NLR（> 2.11）可作为区分特发性 EN 和继发性 EN 的参数。
