Goepfert Melanie, Liebl Patrick, Herth Natalie, Ciarlo Giancarlo, Buentzel Jens, Huebner Jutta
Working Group Integrative Oncology, Dr. Senckenberg Chronomedical Institute, J. W. Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.
Medizinische Klinik II, Hämatologie und internistische Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.
J Cancer Res Clin Oncol. 2017 Oct;143(10):2123-2129. doi: 10.1007/s00432-017-2460-0. Epub 2017 Jun 20.
The aim of this pilot study is to analyze the reactions of healthy test persons and conscious as well as unconscious palliative patients to aroma stimuli.
In a randomized controlled study, healthy probands, conscious and unconscious palliative patients were exposed to two essential oils (lemon, lavender). Water was used as the control stimulus. Physiological parameters (breathing rate and heart rate, oxygen saturation, systolic, diastolic and mean arterial pressure) were measured.
10 test persons (control group), 15 conscious patients and 5 unconscious palliative patients were exposed to the stimuli. Healthy test persons reacted to lemon oil with a significant increase in respiration rate, heart rate and diastolic blood pressure, whereas to lavender oil with a significant decrease in respiration rate was measured. There were no significant reactions concerning the other parameters. Conscious and unconscious patients reacted with a significant increase in all measured parameters to lemon oil and with a significant decrease in all parameters except for oxygen saturation to lavender oil. No significant differences in the reactions were measured between the conscious and unconscious patients and no significant reactions to control stimuli were detected. All physiological reactions were very short and only detectable during stimulus presentation.
Significant physiological reactions were measured after simulation with aroma oils in all three groups in this study. Healthy probands showed different reactions than palliative patients irrespective to their conscious state.
本初步研究旨在分析健康受试人员以及有意识和无意识的姑息治疗患者对香气刺激的反应。
在一项随机对照研究中，将健康受试者、有意识和无意识的姑息治疗患者暴露于两种精油（柠檬、薰衣草）中。用水作为对照刺激物。测量生理参数（呼吸频率、心率、血氧饱和度、收缩压、舒张压和平均动脉压）。
10名受试人员（对照组）、15名有意识患者和5名无意识姑息治疗患者接受了刺激。健康受试人员对柠檬油的反应是呼吸频率、心率和舒张压显著增加，而对薰衣草油的反应是呼吸频率显著降低。其他参数无显著反应。有意识和无意识患者对柠檬油的所有测量参数均显著增加，对薰衣草油的所有参数（除血氧饱和度外）均显著降低。有意识和无意识患者之间的反应无显著差异，对对照刺激物无显著反应。所有生理反应都非常短暂，仅在刺激呈现期间可检测到。
本研究中所有三组在使用香薰油模拟后均测量到显著的生理反应。无论健康受试者的意识状态如何，其反应与姑息治疗患者不同。
