Sato Hideaki, Ishida Masaharu, Motoi Fuyuhiko, Sakata Naoaki, Aoki Takeshi, Kudoh Katsuyoshi, Ohtsuka Hideo, Mizuma Masamichi, Morikawa Takanori, Hayashi Hiroki, Nakagawa Kei, Naitoh Takeshi, Egawa Shinich, Unno Michiaki
Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Division of International Cooperation for Disaster Medicine, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
Surg Today. 2018 Jan;48(1):80-86. doi: 10.1007/s00595-017-1557-z. Epub 2017 Jun 20.
The aim of surgical intervention for chronic pancreatitis (CP) is to relieve symptoms and improve quality of life. However, the precise effect of surgery on the nutritional status of CP patients, which is often impaired by exocrine and endocrine pancreatic dysfunction, has not been elucidated. We conducted this study to evaluate whether Frey's procedure improves the nutritional status of CP patients.
The nutritional status of 35 patients who underwent Frey's procedure for CP at our institute between April 2005 and December 2014, was assessed by the controlling nutritional status (CONUT) scoring before and 1 year after the surgery, and compared with that of seven CP patients who underwent pancreatoduodenectomy. The occurrence of postoperative hepatic steatosis was also monitored.
The nutritional status improved after Frey's procedure, but not after pancreatoduodenectomy. The median postoperative CONUT score after Frey's procedure was significantly lower than the preoperative score (1.0 ± 0.5 vs. 4.0 ± 2.5; p < 0.001).
Frey's procedure is superior to pancreatoduodenectomy for improving the nutritional status of CP patients.
慢性胰腺炎（CP）外科干预的目的是缓解症状并改善生活质量。然而，手术对CP患者营养状况的确切影响尚未阐明，CP患者的营养状况常因胰腺外分泌和内分泌功能障碍而受损。我们开展本研究以评估Frey手术是否能改善CP患者的营养状况。
对2005年4月至2014年12月间在我院接受Frey手术治疗CP的35例患者，在手术前及术后1年采用控制营养状况（CONUT）评分评估其营养状况，并与7例行胰十二指肠切除术的CP患者进行比较。同时监测术后肝脂肪变性的发生情况。
Frey手术后营养状况得到改善，但胰十二指肠切除术后未改善。Frey手术后CONUT评分中位数显著低于术前评分（1.0±0.5对4.0±2.5；p<0.001）。
在改善CP患者营养状况方面，Frey手术优于胰十二指肠切除术。
