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Gain-of-function SNPs in NLRP3 and IL1B genes confer protection against obesity and T2D: undiscovered role of inflammasome genetics in metabolic homeostasis?

作者信息

de Moraes Rodrigues Juliana, Souza de Lima Dhemerson, Leal Vinicius N C, Bosco Adriana A, Sandrim Valeria, Pontillo Alessandra

机构信息

Laboratório de Imunogenética, Departamento of Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo (USP), São Paulo, SP, Brazil.

Nucleo de Pos-Graduacao e Pesquisa-Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.

出版信息

Endocrine. 2018 May;60(2):368-371. doi: 10.1007/s12020-017-1343-0. Epub 2017 Jun 20.

DOI:10.1007/s12020-017-1343-0
PMID:28634744
Abstract
摘要

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本文引用的文献

1
Microbiome, metabolites and host immunity.微生物组、代谢物与宿主免疫。
Curr Opin Microbiol. 2017 Feb;35:8-15. doi: 10.1016/j.mib.2016.10.003. Epub 2016 Nov 22.
2
The NLRP1-IL18 Connection: A Stab in the Back of Obesity-Induced Inflammation.NLRP1-IL18 连接：肥胖诱导炎症的背后一刀。
Cell Metab. 2016 Jan 12;23(1):6-7. doi: 10.1016/j.cmet.2015.12.014.
3
IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.NLRP1 炎性小体产生的白介素-18 可预防肥胖和代谢综合征。
在 COVID-19 中，NLRP3 炎性小体遗传变异与重症疾病相关，这些影响部分通过疾病症状综合来介导：一种形态网络方法。
Mol Psychiatry. 2022 Apr;27(4):1945-1955. doi: 10.1038/s41380-021-01431-4. Epub 2022 Jan 12.
4
Innate-Immunity Genes in Obesity.肥胖中的先天免疫基因。
J Pers Med. 2021 Nov 14;11(11):1201. doi: 10.3390/jpm11111201.
Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22.
4
Is interleukin-1β a culprit in macrophage-adipocyte crosstalk in obesity?白细胞介素-1β是肥胖中巨噬细胞与脂肪细胞相互作用的罪魁祸首吗？
Adipocyte. 2015 Jan 7;4(2):149-52. doi: 10.4161/21623945.2014.979661. eCollection 2015 Apr-Jun.
5
NLRP3 at the interface of metabolism and inflammation.处于代谢与炎症交界的NLRP3
Immunol Rev. 2015 May;265(1):53-62. doi: 10.1111/imr.12285.
6
Serum interleukin-1β in subjects with abdominal obesity and periodontitis.腹部肥胖和牙周炎患者的血清白细胞介素-1β
Obes Res Clin Pract. 2015 Sep-Oct;9(5):513-21. doi: 10.1016/j.orcp.2015.01.005. Epub 2015 Feb 11.
7
NLRPs, microbiota, and gut homeostasis: unravelling the connection.NLRPs、微生物群和肠道稳态：揭示它们之间的联系。
J Pathol. 2014 Aug;233(4):321-30. doi: 10.1002/path.4357. Epub 2014 May 16.
8
Functions of NOD-Like Receptors in Human Diseases.NOD样受体在人类疾病中的功能
Front Immunol. 2013 Oct 16;4:333. doi: 10.3389/fimmu.2013.00333.
9
Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis.采用标准体重指数类别评估全因死亡率与超重和肥胖的关联：系统评价和荟萃分析。
JAMA. 2013 Jan 2;309(1):71-82. doi: 10.1001/jama.2012.113905.
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Integrative inflammasome activity in the regulation of intestinal mucosal immune responses.整合炎症小体在调节肠道黏膜免疫反应中的作用。
Mucosal Immunol. 2013 Jan;6(1):4-13. doi: 10.1038/mi.2012.115. Epub 2012 Dec 5.