肥胖中的先天免疫基因。
Innate-Immunity Genes in Obesity.
作者信息
Mikhailova Svetlana V, Ivanoshchuk Dinara E
机构信息
Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 630090 Novosibirsk, Russia.
Institute of Internal and Preventive Medicine-Branch of Institute of Cytology and Genetics, SB RAS, 630004 Novosibirsk, Russia.
出版信息
J Pers Med. 2021 Nov 14;11(11):1201. doi: 10.3390/jpm11111201.
The main functions of adipose tissue are thought to be storage and mobilization of the body's energy reserves, active and passive thermoregulation, participation in the spatial organization of internal organs, protection of the body from lipotoxicity, and ectopic lipid deposition. After the discovery of adipokines, the endocrine function was added to the above list, and after the identification of crosstalk between adipocytes and immune cells, an immune function was suggested. Nonetheless, it turned out that the mechanisms underlying mutual regulatory relations of adipocytes, preadipocytes, immune cells, and their microenvironment are complex and redundant at many levels. One possible way to elucidate the picture of adipose-tissue regulation is to determine genetic variants correlating with obesity. In this review, we examine various aspects of adipose-tissue involvement in innate immune responses as well as variants of immune-response genes associated with obesity.
脂肪组织的主要功能被认为是储存和调动身体的能量储备、主动和被动体温调节、参与内部器官的空间组织、保护身体免受脂毒性以及异位脂质沉积。在发现脂肪因子后，内分泌功能被添加到上述列表中，并且在确定脂肪细胞与免疫细胞之间的串扰后，又提出了免疫功能。然而，事实证明，脂肪细胞、前脂肪细胞、免疫细胞及其微环境之间相互调节关系的潜在机制在许多层面上是复杂且冗余的。阐明脂肪组织调节情况的一种可能方法是确定与肥胖相关的基因变异。在这篇综述中，我们研究了脂肪组织参与先天免疫反应的各个方面以及与肥胖相关的免疫反应基因变异。
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