Peking University Health Science Center, Beijing, China.
Beijing Center for Disease Prevention and Control, Beijing, China.
Birth Defects Res. 2017 Jul 17;109(13):1011-1019. doi: 10.1002/bdr2.1043. Epub 2017 Jun 21.
Orofacial clefts (OFCs) are common human birth defects in China. However, studies on the prevalence of OFCs present inconsistent results. The overall prevalence and geographic distribution of OFCs are poorly described in China. Thus, we conducted a systematic review and meta-analysis to estimate the prevalence of OFCs.
The systematic review and meta-analysis were conducted on the basis of an established protocol (PROSPERO 2015: CRD42015030198). We systematically searched for articles in four electronic databases, including Embase, PubMed, Wanfang Database, and China National Knowledge Infrastructure (CNKI) to identify relevant studies about prevalence of OFCs in China. Meta-analysis, including subgroup analysis, was conducted to estimate the pooled prevalence.
A total of 41 studies published between 1986 and 2015 were included in our analysis. The sample size ranged from 2,586 to 4,611,808 live births. The random-effects model of meta-analysis showed that the overall prevalence of OFCs in China was 1.4 per 1000 live births (95% confidence interval [CI], 1.1-1.7). In subgroup analysis based on geographic regions, we found that OFC prevalence in Southwest (2.3 per 1000 live births, 95% CI, 1.1-4.7) was higher than that in other regions of China. There were no significant time trends of OFCs during the study period (p-value = 0.47).
The overall prevalence of OFCs in China was 1.4 per 1000 live births. No significant secular trend of prevalence has been found in this analysis. Further studies need to be conducted to explore the etiology of OFC to better control the risk of this common birth defect. Birth Defects Research 109:1011-1019, 2017. © 2017 Wiley Periodicals, Inc.
口腔面部裂（OFCs）是中国常见的人类出生缺陷。然而，有关 OFC 患病率的研究结果不一致。OFC 在我国的总体流行情况和地域分布情况描述较差。因此，我们进行了系统评价和荟萃分析，以估计 OFC 的患病率。
该系统评价和荟萃分析是根据既定方案（PROSPERO 2015：CRD42015030198）进行的。我们系统地在四个电子数据库中搜索文章，包括 Embase、PubMed、万方数据库和中国国家知识基础设施（CNKI），以确定有关中国 OFC 患病率的相关研究。进行荟萃分析，包括亚组分析，以估算汇总患病率。
共纳入了 1986 年至 2015 年期间发表的 41 项研究。样本量范围从 2586 到 4611808 例活产。荟萃分析的随机效应模型显示，中国 OFC 的总体患病率为每 1000 例活产 1.4 例（95％置信区间[CI]，1.1-1.7）。根据地理位置进行的亚组分析中，我们发现中国西南地区（每 1000 例活产 2.3 例，95％CI，1.1-4.7）的 OFC 患病率高于其他地区。在此研究期间，OFC 患病率没有明显的时间趋势（p 值= 0.47）。
中国 OFC 的总体患病率为每 1000 例活产 1.4 例。在这项分析中，没有发现患病率的明显时间趋势。需要进一步研究以探讨 OFC 的病因，从而更好地控制这种常见出生缺陷的风险。出生缺陷研究 109：1011-1019，2017。©2017 Wiley Periodicals，Inc.
