Vieira Karoline Machado, Menezes Verônica Canarim, Cardoso-Dos-Santos Augusto César, Franco Ana Luiza Meneguci Moreira, Carvalho Flavia Martinez de, Faccini Lavinia Schuler, Iser Betine Pinto Moehlecke
Universidade do Sul de Santa Catarina, Curso de Medicina, Tubarão, SC, Brazil.
Ministério da Saúde, Departamento de Ciência e Tecnologia, DF, Brazil.
Epidemiol Serv Saude. 2025 May 12;34:e20240027. doi: 10.1590/S2237-96222025v34e20240027.en. eCollection 2025.
To analyze distribution of orofacial cleft cases (cleft palate, cleft lip and cleft palate with cleft lip) and their temporal trend in Brazil, according to the country's regions and Federative Units from 2010 to 2021, in addition to comparing proportions during the COVID-19 pandemic, from 2020 to 2021, with the preceding time series, from 2010 to 2019.
This is an epidemiological time series study, using records of all babies born with orofacial clefts held on the Live Birth Information System for the period 2010-2021. Prevalence rates were calculated according to year, regions and Federative Units. Time series analysis was performed using the Prais-Winsten generalized linear model.
A total of 34,564,430 live births were recorded in the period. National prevalence of orofacial clefts was 6.73/10,000 live births (95% confidence interval [95%CI 6.64; 6.81])). The Southern region had the highest rate in the period for all types of orofacial clefts. The Northeast region and the states of Alagoas and Piauí showed a rising trend in the period for the three types of orofacial clefts. Other regions showed a stationary trend or increases/decreases in just one type of cleft. Comparing the pre-pandemic period with the pandemic period, there were no significant changes in the prevalence in the Brazilian regions.
Among the country's regions, for all three types of clefts, the South had the highest prevalence, and the Northeast had a rising trend. Among the Federative Units, there was an increase in the three types of clefts in Alagoas and Piauí. The COVID-19 pandemic did not influence prevalence in the period analyzed.
分析2010年至2021年巴西口面部裂隙病例（腭裂、唇裂以及唇腭裂）的分布情况及其时间趋势，具体按照巴西的地区和联邦单位进行分析，此外，还将2020年至2021年新冠疫情期间的比例与2010年至2019年的前一时间序列进行比较。
这是一项流行病学时间序列研究，使用了2010 - 2021年期间活产信息系统中所有口面部裂隙患儿的记录。根据年份、地区和联邦单位计算患病率。使用普雷斯 - 温斯顿广义线性模型进行时间序列分析。
该时期共记录了34564430例活产。口面部裂隙的全国患病率为6.73/10000活产（95%置信区间[95%CI 6.64; 6.81]）。在此期间，南部地区各类口面部裂隙的患病率最高。东北地区以及阿拉戈斯州和皮奥伊州在该时期三种类型的口面部裂隙均呈上升趋势。其他地区呈平稳趋势，或仅有一种类型的裂隙出现增加/减少。将疫情前时期与疫情时期进行比较，巴西各地区的患病率没有显著变化。
在巴西各地区中，对于所有三种类型的裂隙，南部地区患病率最高，东北地区呈上升趋势。在联邦单位中，阿拉戈斯州和皮奥伊州三种类型的裂隙均有所增加。在分析的时期内，新冠疫情并未影响患病率。
