Mortimer Chris J, Wright Chris J
Biomaterials, Biofouling and Biofilms Engineering Laboratory (B3EL), Systems and Process Engineering Centre, College of Engineering, Swansea University, Swansea, UK.
Biotechnol J. 2017 Jul;12(7). doi: 10.1002/biot.201600693. Epub 2017 Jun 21.
This paper reviews the use of iron oxide nanoparticle-nanofiber composites in tissue engineering with a focus on the electrospinning technique. Electrospinning is an established method of scaffold fabrication offering a number of key advantages which include its facile nature, with electrospun materials offering a high surface area to volume ratio, potential for the release of drugs and antimicrobials, controllable fiber diameters and high porosity and permeability. A number of different techniques for the preparation of iron oxide nanoparticles including their functionalization are discussed along with their applications in the biomedical field. The review then focusses on the fabrication of nanoparticle-nanofiber composite scaffolds formed using electrospinning. The advantages and disadvantages of current fabrication techniques are discussed including the fabrication of nanofibers using pre-synthesized nanoparticles and post-treatment synthesized nanoparticles. We demonstrate that emerging in-situ synthesis techniques show promise by offering a reduced number of steps and simpler procedures for the production of magnetic scaffolds. These scaffolds have a number of applications in tissue engineering, allowing for improved bone and tissue repair.
本文综述了氧化铁纳米颗粒-纳米纤维复合材料在组织工程中的应用，重点关注静电纺丝技术。静电纺丝是一种成熟的支架制造方法，具有许多关键优势，包括其简便性，电纺材料具有高的表面积与体积比、药物和抗菌剂释放潜力、可控的纤维直径以及高孔隙率和渗透性。讨论了多种制备氧化铁纳米颗粒的不同技术，包括其功能化，以及它们在生物医学领域的应用。然后，综述聚焦于使用静电纺丝形成的纳米颗粒-纳米纤维复合支架的制造。讨论了当前制造技术的优缺点，包括使用预合成纳米颗粒和后处理合成纳米颗粒制造纳米纤维。我们证明，新兴的原位合成技术通过减少生产磁性支架的步骤数量和简化程序而显示出前景。这些支架在组织工程中有许多应用，可改善骨和组织修复。
