Wang Peng, Mao Yan-Mei, Zhao Chan-Na, Liu Li-Na, Li Xiao-Mei, Li Xiang-Pei, Pan Hai-Feng
1 Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
2 The Key Laboratory of Major Autoimmune Diseases, Anhui Province, Hefei, Anhui, China.
Angiology. 2018 Mar;69(3):228-235. doi: 10.1177/0003319717715964. Epub 2017 Jun 21.
Systemic lupus erythematosus (SLE) is associated with increased cardiovascular risk. This study aims to derive a more precise estimation on pulse wave velocity (PWV) level in patients with SLE and related factors. A literature search was performed using PubMed, EMBASE, and The Cochrane Library databases, studies published up to February 28, 2017, in English. Pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effect or random-effect model analysis. Heterogeneity test was performed by the Q statistic and quantified using I; publication bias was evaluated using a funnel plot and Egger's linear regression test. Of 156 studies found, 27 met eligibility criteria, and 14 studies were finally included in the meta-analysis. Meta-analysis revealed that the SLE group had significantly higher PWV levels than the control group; SMD = 0.56 and 95% CI (0.30-0.82). Subgroup analyses showed that body mass index (BMI), sample size, and disease duration were associated with PWV in patients with SLE. Overall, our study suggests that patients with SLE have a higher PWV level, and it is associated with BMI, sample size, and disease duration.
系统性红斑狼疮（SLE）与心血管疾病风险增加相关。本研究旨在更精确地评估SLE患者的脉搏波速度（PWV）水平及其相关因素。使用PubMed、EMBASE和Cochrane图书馆数据库进行文献检索，检索截至2017年2月28日发表的英文研究。采用固定效应或随机效应模型分析计算合并标准化均数差（SMD）及其95%置信区间（CI）。通过Q统计量进行异质性检验，并用I2进行量化；使用漏斗图和Egger线性回归检验评估发表偏倚。在检索到的156项研究中，27项符合纳入标准，最终14项研究纳入荟萃分析。荟萃分析显示，SLE组的PWV水平显著高于对照组；SMD = 0.56，95%CI（0.30 - 0.82）。亚组分析表明，体重指数（BMI）、样本量和病程与SLE患者的PWV相关。总体而言，我们的研究表明，SLE患者的PWV水平较高，且与BMI、样本量和病程有关。
