Stewart G J, Tyler J P, Cunningham A L, Barr J A, Driscoll G L, Gold J, Lamont B J
Lancet. 1985 Sep 14;2(8455):581-5. doi: 10.1016/s0140-6736(85)90585-9.
Four of eight recipients of artificial insemination (AI) with cryopreserved semen from a symptomless carrier of human T-cell lymphotropic virus type III (HTLV-III) were found to have antibody to the virus. One has generalised, persistent lymphadenopathy while the other three remain symptom free 3 years after insemination. Three subsequently became pregnant more than a year after contact with the infected semen; the children, who are now over 1 year of age, are in good health and do not have HTLV-III antibodies. These observations emphasise the need for a rigorous screening programme for potential AI donors; they also suggest that fresh semen should not be used in AI. The findings confirm the role of semen in heterosexual transmission of the virus and suggest that in women with HTLV-III antibodies pregnancy and subsequent breast-feeding does not necessarily lead to infection of the infant.
在接受来自一名无症状人类T细胞嗜淋巴细胞病毒III型（HTLV-III）携带者冷冻精液进行人工授精（AI）的8名受者中，有4人被发现具有该病毒抗体。其中一人有全身性持续性淋巴结病，而另外三人在授精后3年仍无症状。三人在接触受感染精液一年多后怀孕；现在已超过1岁的孩子身体健康，没有HTLV-III抗体。这些观察结果强调了对潜在人工授精供者进行严格筛查程序的必要性；它们还表明人工授精不应使用新鲜精液。这些发现证实了精液在该病毒异性传播中的作用，并表明患有HTLV-III抗体的女性怀孕及随后的母乳喂养不一定会导致婴儿感染。
