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两种同手性[Ru(bpy)dppz]配合物与聚(U)·聚(A)*聚(U)三链体RNA的结合差异

Binding Differences of Two Homochiral [Ru(bpy)dppz] Complexes with poly(U)·poly(A)*poly(U) Triplex RNA.

作者信息

Peng Meng-Na, Zhu Zhi-Yuan, Tan Li-Feng

机构信息

Key Laboratory of Environment-friendly Chemistry and Application in Ministry of Education and ‡College of Chemistry, Xiangtan University , Xiangtan 411105, China.

出版信息

Inorg Chem. 2017 Jul 3;56(13):7312-7315. doi: 10.1021/acs.inorgchem.7b00670. Epub 2017 Jun 21.

Abstract

The first investigation of chiral ruthenium(II) complexes Δ- and Λ-[Ru(bpy)dppz] and triplex RNA poly(U)·poly(A)*poly(U) was carried out, which showed that Δ enantiomer displayed significant ability in stabilizing model triplex RNA.

摘要

对手性钌(II)配合物Δ-和Λ-[Ru(bpy)dppz]与三链RNA聚(U)·聚(A)*聚(U)进行了首次研究,结果表明Δ对映体在稳定模型三链RNA方面具有显著能力。

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