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冠状动脉搭桥术后房颤的发生率及预测因素:通过当代多中心队列的事件循环记录仪监测进行检测

Incidence and predictors of atrial fibrillation after coronary artery bypass surgery: detection by event loop recorder monitoring from a contemporary multicentre cohort.

作者信息

Abdel-Salam Zainab, Nammas Wail

机构信息

a Department of Cardiology, Faculty of Medicine , Ain Shams University , Cairo , Egypt.

出版信息

Acta Cardiol. 2017 Jun;72(3):311-317. doi: 10.1080/00015385.2017.1304716. Epub 2017 Mar 21.

Abstract

Background Atrial fibrillation (AF) is a frequent complication after cardiac surgery. We explored the incidence and predictors of post-operative AF at 30-day follow-up in an unselected multi-centre cohort of patients undergoing elective coronary artery bypass grafting (CABG) in contemporary practice. Methods and results We enrolled 740 consecutive patients scheduled for elective CABG with or without valve surgery. Cardiac rhythm was continuously monitored for 15 days after surgery by an ambulatory event loop recorder. Clinical follow-up for the occurrence of arrhythmias was performed for the next 15 days by office visits. The primary end point was the incidence of AF at 30-day follow-up. Mean age was 56.5 ± 8.9 years; 69.5% were males; 80% had diabetes. All patients completed 30-day follow-up. At the end of 30 days, AF occurred in 77 patients (10.4%). Most episodes (47 out of 77 episodes, 61%) of AF occurred during post-operative day 2. Episodes of AF were very rare after the first 5 post-operative days (3 out of 77 episodes, 3.9%). Multivariable regression analysis identified the following independent predictors of AF at 30-day follow-up: the lack of beta blocker use (hazard ratio 0.37, 95% confidence interval 0.21-0.64, P < 0.001), and the preoperative left atrial volume index (hazard Ratio 2.21, 95% confidence interval 1.79-2.74, P < 0.001). Conclusions In patients undergoing elective CABG, the incidence of post-operative AF at 30-day follow-up is rather low; the lack of beta blocker use in the perioperative period, and the preoperative left atrial volume index independently predicted the occurrence of AF at 30 days.

摘要

背景

心房颤动(AF)是心脏手术后常见的并发症。我们在当代实践中,对一个未经过筛选的多中心队列中接受择期冠状动脉旁路移植术(CABG)的患者进行了30天随访,以探究术后AF的发生率及预测因素。

方法与结果

我们纳入了740例计划接受择期CABG(无论是否合并瓣膜手术)的连续患者。术后通过动态事件循环记录仪连续监测心律15天。接下来的15天通过门诊就诊对心律失常的发生情况进行临床随访。主要终点是30天随访时AF的发生率。平均年龄为56.5±8.9岁;69.5%为男性;80%患有糖尿病。所有患者均完成了30天随访。在30天结束时,77例患者(10.4%)发生了AF。大多数AF发作(7起中的47起,61%)发生在术后第2天。术后第1个5天后AF发作非常罕见(77起中的3起,3.9%)。多变量回归分析确定了30天随访时AF的以下独立预测因素:未使用β受体阻滞剂(风险比0.37,95%置信区间0.21 - 0.64,P < 0.001),以及术前左心房容积指数(风险比2.21,95%置信区间1.79 - 2.74,P < 0.001)。

结论

在接受择期CABG的患者中,30天随访时术后AF的发生率相当低;围手术期未使用β受体阻滞剂以及术前左心房容积指数可独立预测30天时AF的发生。

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