• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

HLA-F：一种新获准呈递肽的分子。

HLA-F: A New Kid Licensed for Peptide Presentation.

机构信息

Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, 12441 Parklawn Drive, Rockville, MD 20852, USA.

Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, 12441 Parklawn Drive, Rockville, MD 20852, USA.

出版信息

Immunity. 2017 Jun 20;46(6):972-974. doi: 10.1016/j.immuni.2017.06.004.

DOI:10.1016/j.immuni.2017.06.004
PMID:28636965
Abstract

HLA-F, a non-classical MHC molecule, is not known to present peptides. Dulberger et al. (2017) show that HLA-F contains a distinct peptide-binding groove and can present a diverse array of peptides. LIR1, however, recognized HLA-F away from bound peptide, leaving open whether peptide-HLA-F-specific T and NK receptors exist.

摘要

HLA-F 是一种非经典的 MHC 分子，目前已知它不能呈递肽。Dulberger 等人（2017 年）表明，HLA-F 含有独特的肽结合槽，能够呈递多样化的肽。然而，LIR1 识别的 HLA-F 并未结合肽，这使得是否存在肽-HLA-F 特异性 T 和 NK 受体仍不清楚。

相似文献

1
HLA-F: A New Kid Licensed for Peptide Presentation.HLA-F：一种新获准呈递肽的分子。
Immunity. 2017 Jun 20;46(6):972-974. doi: 10.1016/j.immuni.2017.06.004.
2
Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.人类白细胞抗原F呈递肽段并通过与自然杀伤细胞受体相互作用来调节免疫。
Immunity. 2017 Jun 20;46(6):1018-1029.e7. doi: 10.1016/j.immuni.2017.06.002.
3
Changes at the floor of the peptide-binding groove induce a strong preference for proline at position 3 of the bound peptide: molecular dynamics simulations of HLA-A*0217.肽结合凹槽底部的变化导致对结合肽第3位的脯氨酸有强烈偏好：HLA-A*0217的分子动力学模拟
Biopolymers. 2000 Oct 15;54(5):318-27. doi: 10.1002/1097-0282(20001015)54:5<318::AID-BIP30>3.0.CO;2-T.
4
Probing HLA-B7 conformational shifts induced by peptide-binding groove mutations and bound peptide with anti-HLA monoclonal antibodies.利用抗HLA单克隆抗体探究由肽结合凹槽突变和结合肽诱导的HLA - B7构象变化。
J Immunol. 1996 Sep 15;157(6):2470-8.
5
Synthesis and biological evaluation of two chemically modified peptide epitopes for the class I MHC protein HLA-B*2705.针对I类主要组织相容性复合体蛋白HLA - B*2705的两种化学修饰肽表位的合成与生物学评价
Org Biomol Chem. 2006 Oct 21;4(20):3769-77. doi: 10.1039/b611170j. Epub 2006 Sep 8.
6
A structural basis for antigen presentation by the MHC class Ib molecule, Qa-1b.MHC 类 Ib 分子 Qa-1b 呈递抗原的结构基础。
J Immunol. 2012 Jan 1;188(1):302-10. doi: 10.4049/jimmunol.1102379. Epub 2011 Nov 30.
7
Identification of an HLA-DQ2 peptide binding motif and HLA-DPw3-bound self-peptide by pool sequencing.通过混合测序鉴定HLA-DQ2肽结合基序和HLA-DPw3结合的自身肽。
Eur J Immunol. 1994 Feb;24(2):375-9. doi: 10.1002/eji.1830240216.
8
NK cell recognition of MHC class I. NK cells are sensitive to peptide-binding groove and surface alpha-helical mutations that affect T cells.自然杀伤细胞对MHC I类分子的识别。自然杀伤细胞对影响T细胞的肽结合凹槽和表面α螺旋突变敏感。
J Immunol. 1995 Mar 15;154(6):2631-41.
9
Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.HLA-F的功能特性以及HLA-F四聚体与ILT2和ILT4受体的结合
Eur J Immunol. 2000 Dec;30(12):3552-61. doi: 10.1002/1521-4141(200012)30:12<3552::AID-IMMU3552>3.0.CO;2-L.
10
T-cell receptors: tugging on the anchor for a tighter hold on the tumor-associated peptide.T细胞受体：拉住锚定物以更紧密地结合肿瘤相关肽。
Eur J Immunol. 2015 Feb;45(2):380-2. doi: 10.1002/eji.201445385.

引用本文的文献

1
Peptide-specific natural killer cell receptors.肽特异性自然杀伤细胞受体
Oxf Open Immunol. 2025 Apr 17;6(1):iqaf003. doi: 10.1093/oxfimm/iqaf003. eCollection 2025.
2
HLA-F regulates the proliferation of trophoblast via PKM2-dependent glycolysis in the pathogenesis of preeclampsia.在子痫前期发病机制中，HLA - F通过依赖PKM2的糖酵解调节滋养层细胞的增殖。
Mol Med. 2025 Apr 18;31(1):142. doi: 10.1186/s10020-025-01201-w.
3
Targeting of Non-Classical Human Leukocyte Antigens as Novel Therapeutic Strategies in Cancer.靶向非经典人类白细胞抗原作为癌症的新型治疗策略
Cancers (Basel). 2024 Dec 22;16(24):4266. doi: 10.3390/cancers16244266.
4
The role of circular RNA targeting IGF2BPs in cancer-a potential target for cancer therapy.环状 RNA 靶向 IGF2BPs 在癌症中的作用——癌症治疗的潜在靶点。
J Mol Med (Berl). 2024 Nov;102(11):1297-1314. doi: 10.1007/s00109-024-02488-8. Epub 2024 Sep 17.
5
Single-cell profiling reveals immune disturbances landscape and HLA-F-mediated immune tolerance at the maternal-fetal interface in preeclampsia.单细胞分析揭示子痫前期母胎界面免疫紊乱特征及 HLA-F 介导的免疫耐受
Front Immunol. 2023 Oct 3;14:1234577. doi: 10.3389/fimmu.2023.1234577. eCollection 2023.
6
Silencing of circCRIM1 Drives IGF2BP1-Mediated NSCLC Immune Evasion.环状 RNA circCRIM1 通过调控 IGF2BP1 促进非小细胞肺癌免疫逃逸
Cells. 2023 Jan 10;12(2):273. doi: 10.3390/cells12020273.
7
Evolution and molecular interactions of major histocompatibility complex (MHC)-G, -E and -F genes.主要组织相容性复合体 (MHC)-G、-E 和 -F 基因的进化和分子相互作用。
Cell Mol Life Sci. 2022 Aug 4;79(8):464. doi: 10.1007/s00018-022-04491-z.
8
Systematic Analysis of Coronavirus Disease 2019 (COVID-19) Receptor ACE2 in Malignant Tumors: Pan-Cancer Analysis.2019年冠状病毒病（COVID-19）受体ACE2在恶性肿瘤中的系统分析：泛癌分析
Front Mol Biosci. 2020 Oct 23;7:569414. doi: 10.3389/fmolb.2020.569414. eCollection 2020.
9
HLA-G and HLA-F protein isoform expression in breast cancer patients receiving neoadjuvant treatment.乳腺癌患者接受新辅助治疗时 HLA-G 和 HLA-F 蛋白异构体的表达。
Sci Rep. 2020 Sep 25;10(1):15750. doi: 10.1038/s41598-020-72837-3.
10
What the HLA-I!-Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes.什么是 HLA-I！经典和非经典 HLA I 类分子及其在 1 型糖尿病中的潜在作用。
Curr Diab Rep. 2019 Dec 9;19(12):159. doi: 10.1007/s11892-019-1245-z.