Kalampokini S, Lyros E, Luley M, Schöpe J, Spiegel J, Bürmann J, Dillmann U, Fassbender K, Unger M M
a Department of Neurology , University Hospital of Saarland , Homburg , Germany.
b Institute for Medical Biometry, Epidemiology and Medical Informatics , Saarland University , Homburg , Germany.
J Clin Exp Neuropsychol. 2018 Apr;40(3):274-284. doi: 10.1080/13803395.2017.1341470. Epub 2017 Jun 21.
The ability to recognize facial emotion expressions has been reported to be impaired in Parkinson's disease (PD), yet previous studies showed inconsistent findings. The aim of this study was to further investigate facial emotion recognition (FER) in PD patients and its association with demographic and clinical parameters (including motor and nonmotor symptoms).
Thirty-four nondemented PD patients and 24 age- and sex-matched healthy controls (HC) underwent clinical neurological and neuropsychological assessment, standardized olfactory testing with Sniffin' Sticks, and the Ekman 60 Faces Emotion Recognition Test.
PD patients had a significantly lower score on the total FER task than HC (p = .006), even after controlling for the potential confounding factors depression and apathy. The PD group had a specific impairment in the recognition of surprise (p = .007). The recognition of anger approached statistical significance (p = .07). Increasing chronological age and age at disease onset were associated with worse performance on the FER task in PD patients. Olfactory function along with PD diagnosis predicted worse FER performance within all study participants.
Facial emotion recognition and especially the recognition of surprise are significantly impaired in PD patients compared with age- and sex-matched HC. The association of FER with age and olfactory function is endorsed by common structures that undergo neurodegeneration in PD. The relevance of FER in social interaction stresses the clinical relevance and the need for further investigation in this field. Future studies should also determine whether impaired FER is already present in premotor stages of PD.
据报道，帕金森病（PD）患者识别面部情绪表情的能力受损，但先前的研究结果并不一致。本研究的目的是进一步调查PD患者的面部情绪识别（FER）及其与人口统计学和临床参数（包括运动和非运动症状）的关系。
34名无痴呆的PD患者和24名年龄及性别匹配的健康对照者（HC）接受了临床神经学和神经心理学评估、使用嗅觉棒进行的标准化嗅觉测试以及埃克曼60面孔情绪识别测试。
即使在控制了潜在的混杂因素抑郁和冷漠之后，PD患者在FER总任务上的得分仍显著低于HC（p = 0.006）。PD组在惊讶表情识别方面存在特定损伤（p = 0.007）。愤怒表情的识别接近统计学意义（p = 0.07）。在PD患者中，实际年龄和发病年龄的增加与FER任务表现较差有关。嗅觉功能以及PD诊断可预测所有研究参与者中FER表现较差。
与年龄和性别匹配的HC相比，PD患者的面部情绪识别，尤其是惊讶表情的识别明显受损。FER与年龄和嗅觉功能的关联在PD中发生神经退行性变的共同结构中得到证实。FER在社交互动中的相关性强调了该领域的临床相关性和进一步研究的必要性。未来的研究还应确定FER受损是否在PD的运动前期阶段就已存在。
