Hao Zheng, Li Xin, Dai Jin, Zhao Baocheng, Jiang Qing
Center of Diagnosis and Treatment for Developmental Dysplasia of the Hip, Nanjing Zhongyangmen Community Health Service Center, Kang'ai Hospital, Nanjing, 210037, Jiangsu, People's Republic of China.
Department of HIV/AIDS/STI Prevention and Control, Nanjing Municipal Center for Diseases Control and Prevention, Nanjing, 210009, Jiangsu, People's Republic of China.
J Orthop Surg Res. 2017 Jun 20;12(1):94. doi: 10.1186/s13018-017-0594-z.
Knee osteoarthritis (OA) is a complex arthritic condition in which genetic factors play an important role. ADAM12 gene is one of the recognized candidate genes although the results are conflicting. To derive a more precise estimation of the association between rs3740199 polymorphism in ADAM12 gene and risk of knee OA, we performed a meta-analysis based on six related studies, including a total of 2185 cases and 3716 controls.
A comprehensive search was performed to identify related studies up to April 14, 2017. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Different genetic models were used to assess the pooled and stratified data.
Overall, no significant association was found in all genetic models (C vs. G, OR = 0.983, 95% CI = 0.910-1.061; CC vs. GG, OR = 1.033, 95% CI = 0.851-1.255; CG vs. GG, OR = 1.030, 95% CI = 0.877-1.209; CC/CG vs. GG, OR = 1.031, 95% CI = 0.886-1.201; CC vs. CG/GG, OR = 1.017, 95% CI = 0.868-1.190). When stratified by ethnicity, no significant association was found.
This meta-analysis suggested that the rs3740199 polymorphism does not contribute to the development of knee OA. Additional well-designed large studies are required to confirm these findings in different populations.
膝关节骨关节炎（OA）是一种复杂的关节炎病症，其中遗传因素起着重要作用。尽管结果存在矛盾，但ADAM12基因是公认的候选基因之一。为了更精确地估计ADAM12基因中rs3740199多态性与膝关节OA风险之间的关联，我们基于六项相关研究进行了一项荟萃分析，共纳入2185例病例和3716例对照。
进行全面检索以识别截至2017年4月14日的相关研究。我们使用比值比（OR）及其95%置信区间（CI）来评估关联强度。采用不同的遗传模型对汇总数据和分层数据进行评估。
总体而言，在所有遗传模型中均未发现显著关联（C与G相比，OR = 0.983，95%CI = 0.910 - 1.061；CC与GG相比，OR = 1.033，95%CI = 0.851 - 1.255；CG与GG相比，OR = 1.030，95%CI = 0.877 - 1.209；CC/CG与GG相比，OR = 1.031，95%CI = 0.886 - 1.201；CC与CG/GG相比，OR = 1.017，95%CI = 0.868 - 1.190）。按种族分层时，也未发现显著关联。
这项荟萃分析表明，rs3740199多态性与膝关节OA的发生无关。需要更多设计良好的大型研究在不同人群中证实这些发现。
