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The Cytoprotective Effect of Hyperoside against Oxidative Stress Is Mediated by the Nrf2-ARE Signaling Pathway through GSK-3β Inactivation.金丝桃苷通过GSK-3β失活经Nrf2-ARE信号通路介导对氧化应激的细胞保护作用。
PLoS One. 2015 Dec 16;10(12):e0145183. doi: 10.1371/journal.pone.0145183. eCollection 2015.
2
LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1.脂多糖通过引发线粒体酶Alcat1的降解来损害上皮细胞中的氧利用。
J Cell Sci. 2016 Jan 1;129(1):51-64. doi: 10.1242/jcs.176701. Epub 2015 Nov 24.
3
PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners.PRMT1和PRMT4以依赖SIRT1和不依赖SIRT1的方式调节氧化应激诱导的视网膜色素上皮细胞损伤。
Oxid Med Cell Longev. 2015;2015:617919. doi: 10.1155/2015/617919. Epub 2015 Oct 25.
4
Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia.死亡因子4样1蛋白在肺炎小鼠模型中介导上皮细胞死亡。
Sci Transl Med. 2015 Oct 28;7(311):311ra171. doi: 10.1126/scitranslmed.aac7793.
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The ubiquitin E3 ligase SCF-FBXO24 recognizes deacetylated nucleoside diphosphate kinase A to enhance its degradation.泛素E3连接酶SCF-FBXO24识别去乙酰化的核苷二磷酸激酶A以增强其降解。
Mol Cell Biol. 2015 Mar;35(6):1001-13. doi: 10.1128/MCB.01185-14. Epub 2015 Jan 12.
6
High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy.高糖诱导的CARM1表达通过组蛋白3精氨酸17二甲基化调节人视网膜色素上皮细胞凋亡：在糖尿病视网膜病变中的作用
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Asymmetric dimethylarginine in chronic obstructive pulmonary disease (ADMA in COPD).慢性阻塞性肺疾病中的不对称二甲基精氨酸（慢性阻塞性肺疾病中的ADMA）
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8
Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy.泛素化依赖性CARM1降解促进糖尿病肾病中Notch1介导的足细胞凋亡。
Cell Signal. 2014 Sep;26(9):1774-82. doi: 10.1016/j.cellsig.2014.04.008. Epub 2014 Apr 12.
9
Asymmetric dimethylarginine and asthma.不对称二甲基精氨酸与哮喘
Eur Respir J. 2014 Feb;43(2):647-8. doi: 10.1183/09031936.00080313.
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CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.CARM1 通过甲基化染色质重塑因子 BAF155 来增强肿瘤的进展和转移。
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氧化应激通过糖原合酶激酶3β使蛋白质精氨酸甲基转移酶4不稳定，从而阻碍肺上皮细胞迁移。

Oxidative stress destabilizes protein arginine methyltransferase 4 via glycogen synthase kinase 3β to impede lung epithelial cell migration.

作者信息

Li Xiuying, Lai Yandong, Li Jin, Zou Mingyi, Zou Chunbin

机构信息

Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

出版信息

Am J Physiol Cell Physiol. 2017 Sep 1;313(3):C285-C294. doi: 10.1152/ajpcell.00073.2017. Epub 2017 Jun 21.

DOI:10.1152/ajpcell.00073.2017
PMID:28637674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5625095/
Abstract

Oxidative stress impacts normal cellular function leading to the pathogenesis of various diseases including pulmonary illnesses. Protein arginine methyltransferase 4 (PRMT4) is critical for normal lung alveolar epithelial cell development; however, the regulation of PRMT4 within such pulmonary diseases has yet to be elucidated. Using biochemical approaches, we uncovered that peroxide (HO) treatment decreases PRMT4 protein stability in murine lung epithelial (MLE12) cells to impede cell migration. Protein kinase glycogen synthase kinase 3β (GSK-3β) interacts with PRMT4 and catalyzes PRMT4 T132 phosphorylation that protects PRMT4 from ubiquitin proteasomal degradation. HO downregulates GSK-3β to reduce PRMT4 at protein level. PRMT4 promotes cell migration and HO degrades PRMT4 to inhibit lung epithelial cell migration. These observations demonstrate that oxidative stress destabilizes PRMT4 via GSK-3β signaling to impede lung epithelial cell migration that may hinder the lung repair and regeneration process.

摘要

氧化应激影响正常细胞功能，导致包括肺部疾病在内的各种疾病的发病机制。蛋白质精氨酸甲基转移酶4（PRMT4）对正常肺泡上皮细胞发育至关重要；然而，PRMT4在这些肺部疾病中的调节作用尚未阐明。通过生化方法，我们发现过氧化物（HO）处理会降低小鼠肺上皮（MLE12）细胞中PRMT4的蛋白质稳定性，从而阻碍细胞迁移。蛋白激酶糖原合酶激酶3β（GSK-3β）与PRMT4相互作用，并催化PRMT4的T132磷酸化，从而保护PRMT4免受泛素蛋白酶体降解。HO下调GSK-3β，从而在蛋白质水平上降低PRMT4。PRMT4促进细胞迁移，而HO降解PRMT4以抑制肺上皮细胞迁移。这些观察结果表明，氧化应激通过GSK-3β信号通路使PRMT4不稳定，从而阻碍肺上皮细胞迁移，这可能会阻碍肺修复和再生过程。