Ma Zhongrui, Lyu Xinxing, Qin Ning, Liu Haoyu, Zhang Mengrui, Lai Yongchao, Dong Bo, Lu Peiyuan
Medical Research Center, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China.
Department of Immunology, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China.
Genes Dis. 2022 Jun 3;10(6):2383-2392. doi: 10.1016/j.gendis.2022.05.021. eCollection 2023 Nov.
Protein arginine methylation is a common post-translational modification involved in the regulation of various cellular functions. Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that asymmetrically dimethylates histone H3 and non-histone proteins to regulate gene transcription. CARM1 has been found to play important roles in cell differentiation and development, cell cycle progression, autophagy, metabolism, pre-mRNA splicing and transportation, and DNA replication. In this review, we describe the molecular characteristics of CARM1 and summarize its roles in the regulation of cell differentiation and development in mammals.
蛋白质精氨酸甲基化是一种常见的翻译后修饰，参与多种细胞功能的调节。共激活因子相关精氨酸甲基转移酶1（CARM1）是一种蛋白质精氨酸甲基转移酶，可使组蛋白H3和非组蛋白蛋白质发生不对称二甲基化，从而调节基因转录。已发现CARM1在细胞分化与发育、细胞周期进程、自噬、代谢、前体mRNA剪接与转运以及DNA复制中发挥重要作用。在本综述中，我们描述了CARM1的分子特征，并总结了其在哺乳动物细胞分化与发育调节中的作用。
