Wang A D, Costa e Silva I, Symon L, Jewkes D
Neurol Res. 1985 Jun;7(2):58-62. doi: 10.1080/01616412.1985.11739701.
Intraoperative use of somatosensory evoked potentials (SEP's) to monitor intracranial aneurysm surgery and flash visual evoked potentials (F-VEP's) for parasellar surgery have been routinely employed in our clinic. We found that both EP modalities are sensitive to the changing concentration of our standard hypotensive agent, halothane. The prolongation of the N14-N20 interpeak latency to median nerve stimulation at the wrist, and prolongation of P100 latency with altered configuration of early VEP components to flash light stimulation, appear to be the results of direct pharmacological effects of the agent and not an effect of secondary hypotension. VEP is found easily abolished by halothane at a concentration of 2.0%, while the SEP is more resistant. Halothane is not ideal however when monitoring intraoperative VEP.
在我们的诊所中，术中使用体感诱发电位（SEP）来监测颅内动脉瘤手术，使用闪光视觉诱发电位（F-VEP）来监测鞍旁手术已成为常规操作。我们发现这两种诱发电位模式对我们标准降压药氟烷浓度的变化都很敏感。手腕处正中神经刺激时N14-N20峰间潜伏期的延长，以及闪光刺激时早期VEP成分形态改变伴随P100潜伏期的延长，似乎是该药物直接药理作用的结果，而非继发性低血压的影响。发现氟烷在浓度为2.0%时很容易使VEP消失，而SEP则更具耐受性。然而，在监测术中VEP时，氟烷并不理想。
