Al-Mayoof Omar, Al Sughaiyer Hana, Abuomar Wuroud, Khan Maria
Infectious Disease Unit, Rashid Hospital, Dubai, UAE.
Internal Medicine Department, Rashid Hospital, Dubai, UAE.
BMJ Case Rep. 2017 Jun 20;2017:bcr-2016-219022. doi: 10.1136/bcr-2016-219022.
POEMS syndrome (Peripheral neuropathy, Organomegaly, Endocrinopathy, M protein, Skin changes) is a rare plasma cell disorder with multisystem involvementA 40-year-old man with a chronic history of unexplained peripheral neuropathy , presented with exudative ascites.He was found to have an incidental osteolytic lesion of the sacrum proven to be a plasmacytoma. Immunoelectrophoresis for monoclonal protein was negative.In addition, the patient was found to have hepatosplenomegaly, erectile dysfunction, hyperprolactinaemia and hypothyroidism.The patient, was given steroid along with lenalidomide, and showed a good clinical response.
POEMS综合征（周围神经病、脏器肿大、内分泌病、M蛋白、皮肤改变）是一种罕见的累及多系统的浆细胞疾病。一名有不明原因慢性周围神经病病史的40岁男性，出现渗出性腹水。他被偶然发现骶骨有溶骨性病变，经证实为浆细胞瘤。单克隆蛋白免疫电泳为阴性。此外，该患者还存在肝脾肿大、勃起功能障碍、高泌乳素血症和甲状腺功能减退。给予该患者类固醇及来那度胺治疗后，临床反应良好。
