• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

瘢痕疙瘩中细胞因子的原位表达及总胶原蛋白、I型和III型胶原蛋白的形态计量学评估

In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars.

作者信息

da Silva Isabela Rios, Tiveron Luciana Colombo Rodrigues da Cunha, da Silva Marcos Vinicius, Peixoto Alberto Borges, Carneiro Carla Aparecida Xavier, Dos Reis M A, Furtado Pedro Carvalho, Rodrigues Bárbara Rocha, Rodrigues Virmondes, Rodrigues Denise Bertulucci Rocha

机构信息

Federal University of Triângulo Mineiro (UFTM) ICBN and CEFORES, Uberaba, MG, Brazil.

Laboratory of Biopathology and Molecular Biology, University of Uberaba (UNIUBE), Uberaba, MG, Brazil.

出版信息

Mediators Inflamm. 2017;2017:6573802. doi: 10.1155/2017/6573802. Epub 2017 May 30.

DOI:10.1155/2017/6573802
PMID:28638180
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5468593/
Abstract

Keloids are characterized by excessive collagen deposition and growth beyond the edges of the initial injury, and cytokines may be related to their formation. The objective of this study was to evaluate the collagen fibers, analyze in situ expression of cytokines in keloid lesions, and compare to the control group. Results showed that there was a predominance of women and nonwhite and direct black ancestry. Keloid showed a significant increase in total and type III collagen. Significantly, the expression of mRNA for TGF- in keloid was increased, the expressions of IFN-, IFN-R1, and IL-10 were lower, and IFN-R1 and TNF- had no statistical difference. Correlations between collagen type III and TGF- mRNA expression were positive and significant, IFN-, IFN-R1, and IL-10 were negative and significant, and TNF- showed no statistical difference. We conclude that there was a significant increase of total collagen in keloid and predominance of collagen type III compared to the controls, showing keloid as an immature lesion. There is a significant increase in TGF- mRNA in keloid lesions, and a significant decrease in IFN- and IL-10, suggesting that these cytokines are related to keloid lesions.

摘要

瘢痕疙瘩的特征是胶原蛋白过度沉积且生长超出初始损伤边缘，细胞因子可能与其形成有关。本研究的目的是评估瘢痕疙瘩病变中的胶原纤维，分析细胞因子的原位表达，并与对照组进行比较。结果显示，女性、非白人和直接的黑人血统占主导。瘢痕疙瘩中总胶原蛋白和III型胶原蛋白显著增加。值得注意的是，瘢痕疙瘩中转化生长因子（TGF-）的mRNA表达增加，干扰素（IFN-）、干扰素受体1（IFN-R1）和白细胞介素10（IL-10）的表达较低，且干扰素受体1和肿瘤坏死因子（TNF-）无统计学差异。III型胶原蛋白与转化生长因子mRNA表达之间呈显著正相关，与干扰素、干扰素受体1和白细胞介素10呈显著负相关，肿瘤坏死因子无统计学差异。我们得出结论，与对照组相比，瘢痕疙瘩中总胶原蛋白显著增加且III型胶原蛋白占主导，表明瘢痕疙瘩是一种不成熟的病变。瘢痕疙瘩病变中转化生长因子mRNA显著增加，干扰素和白细胞介素10显著减少，表明这些细胞因子与瘢痕疙瘩病变有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/5468593/ececf2a383b1/MI2017-6573802.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/5468593/6734220a4085/MI2017-6573802.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/5468593/3e215a102c62/MI2017-6573802.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/5468593/f20cfef1725d/MI2017-6573802.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/5468593/ececf2a383b1/MI2017-6573802.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/5468593/6734220a4085/MI2017-6573802.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/5468593/3e215a102c62/MI2017-6573802.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/5468593/f20cfef1725d/MI2017-6573802.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bb4/5468593/ececf2a383b1/MI2017-6573802.004.jpg

相似文献

1
In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars.瘢痕疙瘩中细胞因子的原位表达及总胶原蛋白、I型和III型胶原蛋白的形态计量学评估
Mediators Inflamm. 2017;2017:6573802. doi: 10.1155/2017/6573802. Epub 2017 May 30.
2
Expressions of Collagen I and III in Hypoxic Keloid Tissue.缺氧瘢痕疙瘩组织中I型和III型胶原蛋白的表达。
Kobe J Med Sci. 2016 Jul 25;62(3):E58-69.
3
MiR-21 Regulates Keloid Formation by Downregulating Smad7 via the TGF-β/Smad Signaling Pathway.微小RNA-21通过转化生长因子-β/信号转导和转录激活因子信号通路下调Smad7来调节瘢痕疙瘩形成。
J Burn Care Res. 2019 Oct 16;40(6):809-817. doi: 10.1093/jbcr/irz089.
4
Flashlamp pulsed dye laser (PDL) suppression of keloid proliferation through down-regulation of TGF-beta1 expression and extracellular matrix expression.闪光灯脉冲染料激光（PDL）通过下调转化生长因子-β1（TGF-β1）表达和细胞外基质表达来抑制瘢痕疙瘩增殖。
Lasers Surg Med. 2004;34(2):104-8. doi: 10.1002/lsm.10206.
5
[Effects of interferon-gamma on the transforming growth factor beta/Smad pathway in keloid-derived fibroblasts].[干扰素-γ对瘢痕疙瘩来源成纤维细胞中转化生长因子β/Smad信号通路的影响]
Zhonghua Shao Shang Za Zhi. 2009 Dec;25(6):454-9.
6
High in situ mRNA levels of IL-22, TFG-β, and ARG-1 in keloid scars.瘢痕疙瘩中白细胞介素-22、转化生长因子-β和精氨酸酶-1的原位mRNA水平较高。
Immunobiology. 2018 Dec;223(12):812-817. doi: 10.1016/j.imbio.2018.08.010. Epub 2018 Aug 20.
7
Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts.曲格列酮抑制瘢痕疙瘩成纤维细胞中转化生长因子-β1诱导的I型胶原表达。
Br J Dermatol. 2009 Apr;160(4):762-70. doi: 10.1111/j.1365-2133.2008.08989.x. Epub 2008 Dec 2.
8
Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts.抑制Smad3表达可降低瘢痕疙瘩疾病成纤维细胞中的胶原蛋白合成。
J Plast Reconstr Aesthet Surg. 2007;60(11):1193-9. doi: 10.1016/j.bjps.2006.05.007. Epub 2007 Jan 19.
9
Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression.中重度哮喘中与气道重塑相关的介质：类固醇对转化生长因子-β、白细胞介素-11、白细胞介素-17以及Ⅰ型和Ⅲ型胶原表达的影响
J Allergy Clin Immunol. 2003 Jun;111(6):1293-8. doi: 10.1067/mai.2003.1557.
10
Exogenous nitric oxide stimulated collagen type I expression and TGF-beta1 production in keloid fibroblasts by a cGMP-dependent manner.外源性一氧化氮通过环磷酸鸟苷（cGMP）依赖性方式刺激瘢痕疙瘩成纤维细胞中I型胶原蛋白的表达和转化生长因子-β1（TGF-β1）的产生。
Nitric Oxide. 2007 Mar;16(2):258-65. doi: 10.1016/j.niox.2006.09.002. Epub 2006 Sep 12.

引用本文的文献

1
Ubiquitin-related Protein IFNGR1 as Causal Factor and Drug Target for Keloids: A Mendelian Randomization Analysis.泛素相关蛋白IFNGR1作为瘢痕疙瘩的致病因素和药物靶点：一项孟德尔随机化分析
Plast Reconstr Surg Glob Open. 2025 Aug 18;13(8):e7028. doi: 10.1097/GOX.0000000000007028. eCollection 2025 Aug.
2
Cytokines, chemokines and growth factors involved in keloids pathogenesis.参与瘢痕疙瘩发病机制的细胞因子、趋化因子和生长因子。
An Bras Dermatol. 2025 Mar-Apr;100(2):300-307. doi: 10.1016/j.abd.2024.01.010. Epub 2025 Jan 10.
3
Post-Excision Soft X-Ray Radiotherapy for Keloids: Experience in a Tertiary Referral Center.

本文引用的文献

1
Expressions of Collagen I and III in Hypoxic Keloid Tissue.缺氧瘢痕疙瘩组织中I型和III型胶原蛋白的表达。
Kobe J Med Sci. 2016 Jul 25;62(3):E58-69.
2
Determination of skin wound age by using cytokines as potential markers.利用细胞因子作为潜在标志物测定皮肤伤口的愈合时间。
J Forensic Leg Med. 2016 Nov;44:14-19. doi: 10.1016/j.jflm.2016.08.011. Epub 2016 Aug 24.
3
Efficacy of custom-made pressure clips for ear keloid treatment after surgical excision.定制压力夹在手术切除后耳部瘢痕疙瘩治疗中的疗效。
切除后软 X 射线放射治疗瘢痕疙瘩：三级转诊中心的经验。
Dermatology. 2024;240(4):572-580. doi: 10.1159/000539782. Epub 2024 Jun 19.
4
Identification of a potential bioinformatics-based biomarker in keloids and its correlation with immune infiltration.瘢痕疙瘩中基于生物信息学的潜在生物标志物的鉴定及其与免疫浸润的相关性。
Eur J Med Res. 2023 Nov 2;28(1):476. doi: 10.1186/s40001-023-01421-y.
5
Keloidal Collagen May Be Produced Directly by αSMA-positive Cells: Morphological Analysis and Protein Shotgun Analysis.瘢痕疙瘩胶原蛋白可能由α平滑肌肌动蛋白阳性细胞直接产生：形态学分析和蛋白质鸟枪法分析。
Plast Reconstr Surg Glob Open. 2023 Apr 10;11(4):e4897. doi: 10.1097/GOX.0000000000004897. eCollection 2023 Apr.
6
Melatonin influences the biological characteristics of keloid fibroblasts through the Erk and Smad signalling pathways.褪黑素通过Erk和Smad信号通路影响瘢痕疙瘩成纤维细胞的生物学特性。
Burns Trauma. 2023 Mar 1;11:tkad005. doi: 10.1093/burnst/tkad005. eCollection 2023.
7
Immune cells and associated molecular markers in dermal fibrosis with focus on raised cutaneous scars.真皮纤维化中的免疫细胞及相关分子标志物——以隆起性皮肤瘢痕为例。
Exp Dermatol. 2023 May;32(5):570-587. doi: 10.1111/exd.14734. Epub 2023 Feb 20.
8
The Inhibition of Adipose-Derived Stem Cells on the Invasion of Keloid Fibroblasts.脂肪来源干细胞对瘢痕成纤维细胞侵袭的抑制作用。
Int J Med Sci. 2022 Oct 3;19(12):1796-1805. doi: 10.7150/ijms.68646. eCollection 2022.
9
Nanofiber/hydrogel core-shell scaffolds with three-dimensional multilayer patterned structure for accelerating diabetic wound healing.具有三维多层图案结构的纳米纤维/水凝胶核壳支架，用于加速糖尿病伤口愈合。
J Nanobiotechnology. 2022 Jan 8;20(1):28. doi: 10.1186/s12951-021-01208-5.
10
Multiple Cytokines Elevated in Patients with Keloids: Is It an Indication of Auto-Inflammatory Disease?瘢痕疙瘩患者多种细胞因子升高：这是否提示自身炎症性疾病？
J Inflamm Res. 2021 Jun 10;14:2465-2470. doi: 10.2147/JIR.S312091. eCollection 2021.
J Plast Reconstr Aesthet Surg. 2016 Jan;69(1):115-21. doi: 10.1016/j.bjps.2015.09.013. Epub 2015 Oct 9.
4
Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo.肿瘤坏死因子-α加速人皮肤中I型胶原蛋白的降解与离体状态下基质金属蛋白酶（MMP）-1和MMP-3水平升高有关。
Eur J Cell Biol. 2015 Jan;94(1):12-21. doi: 10.1016/j.ejcb.2014.10.001. Epub 2014 Oct 23.
5
Skin equivalent tensional force alters keloid fibroblast behavior and phenotype.皮肤等效张力改变瘢痕疙瘩成纤维细胞的行为和表型。
Wound Repair Regen. 2014 Sep-Oct;22(5):557-68. doi: 10.1111/wrr.12215.
6
Picrosirius red staining: a useful tool to appraise collagen networks in normal and pathological tissues.天狼星红苦味酸染色法：评估正常和病理组织中胶原网络的有用工具。
J Histochem Cytochem. 2014 Oct;62(10):751-8. doi: 10.1369/0022155414545787. Epub 2014 Jul 14.
7
Anti-fibrotic actions of interleukin-10 against hypertrophic scarring by activation of PI3K/AKT and STAT3 signaling pathways in scar-forming fibroblasts.白细胞介素-10通过激活瘢痕形成成纤维细胞中的PI3K/AKT和STAT3信号通路对肥厚性瘢痕形成的抗纤维化作用。
PLoS One. 2014 May 30;9(5):e98228. doi: 10.1371/journal.pone.0098228. eCollection 2014.
8
Studying intense pulsed light method along with corticosteroid injection in treating keloid scars.研究强脉冲光疗法联合皮质类固醇注射治疗瘢痕疙瘩。
Iran Red Crescent Med J. 2014 Feb;16(2):e12464. doi: 10.5812/ircmj.12464. Epub 2014 Feb 5.
9
Efficacy and safety of an advanced formula silicone gel for prevention of post-operative scars.一种先进配方的硅凝胶预防术后瘢痕的疗效和安全性。
Dermatol Ther (Heidelb). 2013 Dec;3(2):157-67. doi: 10.1007/s13555-013-0036-8. Epub 2013 Nov 20.
10
A novel hydrogel scaffold for the prevention or reduction of the recurrence of keloid scars postsurgical excision.
J Am Acad Dermatol. 2013 Nov;69(5):828-830. doi: 10.1016/j.jaad.2013.06.025.