Samareh Fekri Mitra, Hashemi-Bajgani Seyed-Mehdi, Naghibzadeh-Tahami Ahmad, Arabnejad Fateme
Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Department of Internal Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Tanaffos. 2017;16(1):34-39.
Chronic obstructive pulmonary disease (COPD) is one of the most important causes of morbidity and mortality worldwide. The complications of COPD are numerous, and cognitive impairment is one of the most common complications that relates to mortality and morbidity directly. The present study was conducted with the aim of evaluating the prevalence of cognitive impairment in patients with COPD in comparison to normal individuals.
In this case-control study, 87 patients with COPD, whose diagnoses were confirmed by a pulmonologist based on the spirometry test findings, were included. The mini-mental state examination (MMSE) questionnaire was administered for assessing the cognitive impairment. Arterial oxygen saturation was measured. The MMSE questionnaires were administered to 60 healthy, age-and-sex-matched individuals without a history of myocardial infarction or cerebrovascular infarction, and their arterial oxygen saturations were measured. The data were analyzed using the SPSS (version 20) software.
In the case group, 42 patients (48.27%) had no cognitive impairment, 39 (44.82%) had mild, and 6 (6.89%) had moderate cognitive impairment. In the control group, 38 (63.33%) had no cognitive impairment, 20 (33.33%) mild and 2 (3.33 %) moderate cognitive impairment. There were significant relationships between the cognitive impairment and arterial oxygen saturation, severity of COPD, and higher age. The prevalence of cognitive impairment was 51.71% in the case group and 36.66% in the control group.
According the results of the present study, COPD increased the risk of cognitive impairment significantly and is related to the severity of COPD, arterial oxygen saturation, and higher age.
慢性阻塞性肺疾病（COPD）是全球发病和死亡的最重要原因之一。COPD的并发症众多，认知障碍是最常见的并发症之一，直接关系到死亡率和发病率。本研究旨在评估COPD患者与正常个体相比认知障碍的患病率。
在这项病例对照研究中，纳入了87例COPD患者，其诊断由肺科医生根据肺活量测定试验结果确认。采用简易精神状态检查表（MMSE）问卷评估认知障碍。测量动脉血氧饱和度。对60名无心肌梗死或脑血管梗死病史、年龄和性别匹配的健康个体进行MMSE问卷调查，并测量其动脉血氧饱和度。使用SPSS（20版）软件分析数据。
病例组中，42例患者（48.27%）无认知障碍，39例（44.82%）有轻度认知障碍，6例（6.89%）有中度认知障碍。对照组中，38例（63.33%）无认知障碍，20例（33.33%）有轻度认知障碍，2例（3.33%）有中度认知障碍。认知障碍与动脉血氧饱和度、COPD严重程度和较高年龄之间存在显著关系。病例组认知障碍患病率为51.71%，对照组为36.66%。
根据本研究结果，COPD显著增加了认知障碍的风险，且与COPD严重程度、动脉血氧饱和度和较高年龄有关。
