Health and Rehabilitation Sciences Research Institute, University of Ulster, Jordanstown, UK.
Respir Physiol Neurobiol. 2011 Jun 30;177(1):36-40. doi: 10.1016/j.resp.2011.03.007. Epub 2011 Mar 22.
Air travel may cause significant hypoxia in passengers with chronic obstructive pulmonary disease (COPD). It is not known whether this level of hypoxia will cause impairment in cognitive function. The aim of this study was to determine the effect of hypoxia on cognitive performance in patients with COPD when Pa(O2) was decreased <6.6 kPa. In ten patients with moderate to severe COPD trail making tasks and complex figure tasks were used to assess cognitive performance when the patients breathed 21% O(2), and when Pa(O2) was decreased to <6.6 kPa. During administration of 21% O(2), Pa(O2) was 9.5 (8.9-10.2) kPa. When Sp(O2) was decreased to 85% via manipulation of the FI(O2) (inspired fraction of oxygen) Pa(O2), decreased to 6.1 (5.9-6.2) kPa. No short term deterioration in visual search, mental flexibility or visuospatial constructional ability was detected when Pa(O2) was decreased to <6.6 kPa. The results show that short term exposure to hypoxia had no adverse effect on cognitive function.
航空旅行可能会导致慢性阻塞性肺疾病（COPD）患者出现显著的低氧血症。目前尚不清楚这种程度的低氧血症是否会导致认知功能障碍。本研究旨在确定当 Pa(O2) 降低至<6.6 kPa 时，低氧血症对 COPD 患者认知功能的影响。在 10 名中重度 COPD 患者中，采用连线测试和复杂图形测试来评估患者在吸入 21% O(2)时以及当 Pa(O2) 降低至<6.6 kPa 时的认知表现。在吸入 21% O(2)时，Pa(O2)为 9.5（8.9-10.2）kPa。通过调节 FI(O2)（吸入氧气分数）使 Sp(O2)降低至 85%，Pa(O2)降低至 6.1（5.9-6.2）kPa。当 Pa(O2) 降低至<6.6 kPa 时，未检测到视觉搜索、思维灵活性或视空间构建能力的短期恶化。结果表明，短期暴露于低氧血症对认知功能没有不良影响。
