Kovesdy Csaba P, L Furth Susan, Zoccali Carmine
Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Nephrology Section, Memphis VA Medical Center, Memphis, TN, USA.
Clin Kidney J. 2017 Feb;10(1):1-8. doi: 10.1093/ckj/sfw139. Epub 2017 Jan 25.
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk factors for new-onset CKD. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long term. The incidence of obesity-related glomerulopathy has increased 10-fold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis, and for a number of malignancies including kidney cancer. This year World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyles and health policy measures that make preventive behaviors an affordable option.
肥胖已成为全球性的流行病，预计其患病率在未来十年将增长40%。这种患病率的上升对糖尿病、心血管疾病以及慢性肾脏病（CKD）的风险都有影响。高体重指数是新发CKD最强的风险因素之一。在肥胖个体中，会发生代偿性超滤过以满足体重增加所带来的更高代谢需求。肾小球内压力的升高会损害肾脏，并长期增加患CKD的风险。近年来，肥胖相关肾小球病的发病率增加了10倍。肥胖还被证明是肾结石以及包括肾癌在内的多种恶性肿瘤的风险因素。今年的世界肾脏日宣传肥胖的有害后果及其与肾脏疾病的关联，倡导健康的生活方式和健康政策措施，使预防行为成为人们能够负担得起的选择。
