Debowski Jedrzej A, Wærp Cora, Kjellevold Stig A, Abedini Sadollah
Department of Nephrology, Sykehuset i Vestfold HF, Tonsberg, Norway.
Division of Nephrology, Department of Medicine, Sykehuset i Vestfold, Tonsberg, Norway.
Clin Kidney J. 2017 Feb;10(1):131-134. doi: 10.1093/ckj/sfw089. Epub 2016 Sep 16.
Catheter-related infections in peritoneal dialysis (PD) remain a significant complication, and some patients with recurrent exit-site (ESI) and/or tunnel infections may experience external cuff extrusion. In these cases, cuff-shaving has been described as a possible course of treatment. During a 4-year period, there were 44 patients with PD at our department; all received double-cuffed Tenckhoff catheters. Six (13%) never started on PD. Five (13%) of the 38 active PD patients experienced cuff extrusion. Causes of end-stage renal disease (ESRD) were diabetic nephropathy ( = 1), toxic nephropathy ( = 1), hypertensive nephrosclerosis ( = 1), systemic disease ( = 1) and one with unknown cause. PD catheters were inserted by the Department of Surgery and our patients waited a mean of 3.71 weeks (0.57-7.86) from catheter insertion to PD start. Patients were followed up by monthly and even fortnightly during infections. Our cohort experienced two (1-5) ESIs per patient prior to cuff extrusion. Cultures showed growth of and the patients received dicloxacillin orally 500 mg qid for 3-4 weeks. Of the 38 active PD patients, 5 (13%) developed cuff extrusion with an incidence of 0.20 episodes/patient/year, manifesting on average at 32 weeks (17.3-40.6), due to repeated ESI in four patients and substantial weight loss in one patient. All five underwent cuff-shaving and the ESIs resolved completely in 80% of the cases assisted by supplemental treatment with mupirocin and/or dicloxacillin. There were no complications to the cuff-shaving procedure itself. None of the five patients experienced new ESIs after cuff-shaving had been performed. Cuff-shaving reduces the rate of recurring ESIs. The procedure is safe, if performed correctly, and poses no risk to the patient or the catheter.
腹膜透析(PD)相关的导管感染仍然是一个严重的并发症,一些反复出现出口部位(ESI)和/或隧道感染的患者可能会出现外部袖套挤出。在这些情况下,袖套修剪已被描述为一种可能的治疗方法。在4年期间,我们科室有44例PD患者;所有患者均接受了双袖套Tenckhoff导管。6例(13%)从未开始进行PD治疗。38例活跃的PD患者中有5例(13%)出现袖套挤出。终末期肾病(ESRD)的病因包括糖尿病肾病(=1)、中毒性肾病(=1)、高血压性肾硬化(=1)、全身性疾病(=1)以及1例病因不明。PD导管由外科插入,我们的患者从导管插入到开始PD治疗的平均等待时间为3.71周(0.57 - 7.86周)。在感染期间,患者每月甚至每两周接受一次随访。在袖套挤出之前,我们的队列中每位患者经历了2次(1 - 5次)ESI。培养结果显示有生长,患者口服双氯西林500 mg,每日4次,持续3 - 4周。在38例活跃的PD患者中,5例(13%)出现袖套挤出,发生率为0.20次/患者/年,平均在32周(17.3 - 40.6周)出现,其中4例是由于反复的ESI,1例是由于体重显著减轻。所有5例患者均接受了袖套修剪,在莫匹罗星和/或双氯西林辅助治疗的情况下,80%的病例中ESI完全缓解。袖套修剪手术本身没有并发症。5例患者在进行袖套修剪后均未出现新的ESI。袖套修剪降低了ESI复发率。如果操作正确,该手术是安全的,对患者或导管均无风险。