Goldberg S C
Schizophr Bull. 1985;11(3):453-6. doi: 10.1093/schbul/11.3.453.
Five large-scale placebo-controlled studies are cited to show that, contrary to the contention of Johnstone et al. (1976) and Crow (1980), negative and/or deficit symptoms in schizophrenia do indeed respond to neuroleptic treatment. Further evidence is given that it is the "organic-like" symptoms (visual and olfactory hallucinations, disorientation, and memory deficit) that do not respond to neuroleptics. This would more sensibly reformulate the hypothesis of Johnstone et al. (1976) and Crow (1980) to state that schizophrenic patients with enlarged ventricles tend to show symptoms of organicity and tend not to respond to neuroleptics.
五项大规模安慰剂对照研究被引用来表明，与约翰斯通等人（1976年）和克劳（1980年）的观点相反，精神分裂症中的阴性和/或缺陷症状确实对抗精神病药物治疗有反应。进一步的证据表明，“类器质性”症状（视觉和嗅觉幻觉、定向障碍和记忆缺陷）对抗精神病药物没有反应。这将更合理地重新表述约翰斯通等人（1976年）和克劳（1980年）的假设，即脑室扩大的精神分裂症患者往往表现出器质性症状，并且往往对抗精神病药物没有反应。
