Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Sci China Life Sci. 2017 Jun;60(6):601-616. doi: 10.1007/s11427-017-9047-4. Epub 2017 May 29.
Numerous experimental and clinical studies indicate that chronic inflammation is closely related to the initiation, progression, and spread of cancer, in which proinflammatory cytokines, such as interleukin (IL)-6, IL-1β, and tumor necrosis factor-α (TNF-α), and transcription factors, such as nuclear factor-κB (NF-κB), and signal transducer and activator of transcription 3 (STAT3), play pivotal roles. Stimulated by proinflammatory cytokines, NF-κB and STAT3 can modulate the expression of target genes, most of which are oncogenic ones, and promote the survival, proliferation, invasion, and metastasis of cancer cells. Now it is generally accepted that inflammation-related molecules and pathways are useful targets for the prevention and treatment of cancer. In this review, we summarize the relationship between chronic inflammation and cancer and describe some potentially useful agents including aspirin, meformin, statins, and some natural products (green tea catechins, andrographolide, curcumin) for their cancer prevention and treatment activities targeting chronic inflammation. The results of typical clinical studies are included, and the influences of these agents on the proinflammatory cytokines and inflammation-related pathways are discussed. Data from the present review support that agents targeting chronic inflammation may have a broad application prospect for the prevention and treatment of cancer in the future.
大量的实验和临床研究表明，慢性炎症与癌症的发生、发展和扩散密切相关，其中促炎细胞因子，如白细胞介素（IL）-6、IL-1β 和肿瘤坏死因子-α（TNF-α），以及转录因子，如核因子-κB（NF-κB）和信号转导和转录激活因子 3（STAT3），起着关键作用。促炎细胞因子刺激 NF-κB 和 STAT3 可以调节靶基因的表达，其中大多数是致癌基因，并促进癌细胞的存活、增殖、侵袭和转移。现在人们普遍认为，与炎症相关的分子和途径是预防和治疗癌症的有用靶点。在这篇综述中，我们总结了慢性炎症与癌症之间的关系，并描述了一些潜在有用的药物，包括阿司匹林、二甲双胍、他汀类药物和一些天然产物（绿茶儿茶素、穿心莲内酯、姜黄素），它们通过靶向慢性炎症来预防和治疗癌症。包括了典型临床研究的结果，并讨论了这些药物对促炎细胞因子和炎症相关途径的影响。本综述中的数据支持靶向慢性炎症的药物在未来可能具有广泛的预防和治疗癌症的应用前景。
