Li Xiaohong, Yuan Weichen, Wu Jibiao, Zhen Jianhua, Sun Qihui, Yu Minmin
First Clinical School of Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
Front Pharmacol. 2022 Sep 27;13:920435. doi: 10.3389/fphar.2022.920435. eCollection 2022.
Botanicals have attracted much attention in the field of anti-inflammatory due to their good pharmacological activity and efficacy. is a natural plant ingredient that is widely used around the world. Andrographolide is the main active ingredient derived from , which has a good effect on the treatment of inflammatory diseases. This article reviews the application, anti-inflammatory mechanism and molecular targets of andrographolide in different inflammatory diseases, including respiratory, digestive, immune, nervous, cardiovascular, skeletal, and tumor system diseases. And describe its toxicity and explain its safety. Studies have shown that andrographolide can be used to treat inflammatory lesions of various systemic diseases. In particular, it acts on many inflammation-related signalling pathways. The future direction of andrographolide research is also introduced, as is the recent research that indicates its potential clinical application as an anti-inflammatory agent.
植物药因其良好的药理活性和疗效而在抗炎领域备受关注。穿心莲内酯是一种在全球广泛使用的天然植物成分。穿心莲内酯是从穿心莲中提取的主要活性成分，对炎症性疾病的治疗有良好效果。本文综述了穿心莲内酯在不同炎症性疾病中的应用、抗炎机制和分子靶点，包括呼吸、消化、免疫、神经、心血管、骨骼和肿瘤系统疾病。并描述其毒性并解释其安全性。研究表明，穿心莲内酯可用于治疗各种全身性疾病的炎症性病变。特别是，它作用于许多与炎症相关的信号通路。还介绍了穿心莲内酯研究的未来方向，以及表明其作为抗炎剂潜在临床应用的最新研究。
