Xiong Qin, Hu Xiang, Xu Yiting, Zhang Xueli, Pan Xiaoping, Xiao Yunfeng, Ma Xiaojing, Bao Yuqian, Jia Weiping
1Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China 2Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Menopause. 2017 Nov;24(11):1289-1294. doi: 10.1097/GME.0000000000000917.
Depression is one of the most common mental disorders, and women are more vulnerable to depression than men, particularly during stages of hormonal fluctuations. After menopause, fat accumulation shifts from the subcutaneous area to the visceral area, and the risk of metabolic disorder increases in parallel. The present study aimed to evaluate the association between abdominal fat distribution and the presence of depressive symptoms in postmenopausal women.
Visceral fat area (VFA) was detected by magnetic resonance imaging. Depressive symptoms were evaluated with Zung's Self-Rating Depression Scale.
In all, 437 normoglycemic postmenopausal women with a mean age of 58.4 ± 5.0 years (mean age at final menstrual period: 50.1 ± 3.5 years) were enrolled in the present study, including 117 individuals with depressive symptoms and 320 individuals without depressive symptoms. The prevalence of abdominal obesity in women with depressive symptoms was much higher than that in those without depressive symptoms (37.6% vs 27.5%; P = 0.042). Participants with depressive symptoms showed elevated VFA values (74.6 ± 29.8 vs 65.9 ± 28.9 cm; P = 0.006). Multivariate stepwise regression analysis demonstrated that VFA was independently correlated with the presence of depressive symptoms (standardized β = 0.099, P = 0.012).
In Chinese postmenopausal women, visceral fat accumulation was an independent and positive factor significantly associated with the presence of depressive symptoms.
抑郁症是最常见的精神障碍之一，女性比男性更容易患抑郁症，尤其是在激素波动阶段。绝经后，脂肪堆积从皮下区域转移到内脏区域，代谢紊乱的风险也随之增加。本研究旨在评估绝经后女性腹部脂肪分布与抑郁症状之间的关联。
通过磁共振成像检测内脏脂肪面积（VFA）。用zung自评抑郁量表评估抑郁症状。
本研究共纳入437名血糖正常的绝经后女性，平均年龄58.4±5.0岁（末次月经平均年龄：50.1±3.5岁），其中有抑郁症状者117例，无抑郁症状者320例。有抑郁症状的女性腹部肥胖患病率远高于无抑郁症状的女性（37.6%对27.5%；P=0.042）。有抑郁症状的参与者VFA值升高（74.6±29.8对65.9±28.9cm；P=0.006）。多因素逐步回归分析表明，VFA与抑郁症状的存在独立相关（标准化β=0.099，P=0.012）。
在中国绝经后女性中，内脏脂肪堆积是与抑郁症状存在显著相关的独立正向因素。
