Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
Chem Soc Rev. 2017 Jul 3;46(13):3886-3903. doi: 10.1039/c7cs00207f.
Surface-enhanced Raman scattering (SERS) spectroscopy has evolved into a cross-disciplinary analytical technique by unveiling relevant chemical, biological, material, and structural information. The focus of this review is on two critical properties for successfully expanding applications of SERS spectroscopy: quality of the plasmonic substrate and molecule localization to the substrate. In this review, we discuss recent work on quantifying SERS distance dependence, key factors for substrate characterization and performance evaluation, expansion of SERS applications through substrate development for UV plasmonics and short-distance capture strategies for optimizing analyte-surface structures. After surveying the recent developments of these seemingly disparate fields, we suggest new research directions that may originate from a synergistic blend of all the herein discussed topics. Finally, we discuss major challenges and open questions related to the application of SERS for understanding of chemical processes at the nanoscale, with special interest on in situ catalysts and biosensing.
表面增强拉曼散射（SERS）光谱学通过揭示相关的化学、生物、材料和结构信息，已经发展成为一种跨学科的分析技术。本文的重点是成功扩展 SERS 光谱学应用的两个关键特性：等离子体基底的质量和分子在基底上的定位。在这篇综述中，我们讨论了最近在量化 SERS 距离依赖性、基底表征和性能评估的关键因素、通过开发用于紫外等离子体和短距离捕获策略的基底来扩展 SERS 应用方面的工作，这些策略旨在优化分析物-表面结构。在调查了这些看似不同领域的最新进展之后，我们提出了可能源于所有在此讨论的主题协同融合的新研究方向。最后，我们讨论了与纳米尺度上化学过程理解相关的 SERS 应用的主要挑战和未解决的问题，特别关注原位催化剂和生物传感。
