Lee E H
Behav Brain Res. 1985 Sep;17(1):59-66. doi: 10.1016/0166-4328(85)90007-5.
The results of a dose-response study of the effects of nicotine on exploratory behavior in male rats is reported. Nicotine at 0.5 mg/kg elevated locomotor activity without significantly changing other parameters of exploration. Low-dose nicotine (0.2 mg/kg) did not produce any effect on exploration measures, while high-dose nicotine (0.8 mg/kg) produced a state of ataxia in animals and decreased most exploration measures in general. Additional, nicotine at high doses seems to reduce the animal's state of fear/anxiety, while at low dose the drug seems to increase the animal's level of curiosity in a novel environment. Biochemically, nicotine has been found to accelerate dopamine synthesis and norepinephrine turnover, and to decrease serotonin turnover. More importantly, the amino acid precursors tyrosine and tryptophan were found to be the neurochemical measures most related to the behavioral changes produced by nicotine.
本文报告了一项关于尼古丁对雄性大鼠探索行为影响的剂量反应研究结果。0.5毫克/千克的尼古丁可提高运动活性，但不会显著改变其他探索参数。低剂量尼古丁（0.2毫克/千克）对探索指标没有任何影响，而高剂量尼古丁（0.8毫克/千克）会使动物出现共济失调状态，并总体上降低大多数探索指标。此外，高剂量尼古丁似乎会降低动物的恐惧/焦虑状态，而低剂量时该药物似乎会提高动物在新环境中的好奇心水平。在生化方面，已发现尼古丁可加速多巴胺合成和去甲肾上腺素周转，并降低血清素周转。更重要的是，发现氨基酸前体酪氨酸和色氨酸是与尼古丁产生的行为变化最相关的神经化学指标。
