C1q/TNF相关蛋白3（CTRP3）的功能与调控
C1q/TNF-Related Protein 3 (CTRP3) Function and Regulation.
作者信息
Li Ying, Wright Gary L, Peterson Jonathan M
机构信息
Quillen College of Medicine, Department of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee, USA.
College of Public Health, Department of Health Sciences, East Tennessee State University, Johnson City, Tennessee, USA.
出版信息
Compr Physiol. 2017 Jun 18;7(3):863-878. doi: 10.1002/cphy.c160044.
Abstract
As the largest endocrine organ, adipose tissue secretes many bioactive molecules that circulate in blood, collectively termed adipokines. Efforts to identify such metabolic regulators have led to the discovery of a family of secreted proteins, designated as C1q tumor necrosis factor (TNF)-related proteins (CTRPs). The CTRP proteins, adiponectin, TNF-alpha, as well as other proteins with the distinct C1q domain are collectively grouped together as the C1q/TNF superfamily. Reflecting profound biological potency, the initial characterization of these adipose tissue-derived CTRP factors finds wide-ranging effects upon metabolism, inflammation, and survival-signaling in multiple tissue types. CTRP3 (also known as CORS26, cartducin, or cartonectin) is a unique member of this adipokine family. In this review we provide a comprehensive overview of the research concerning the expression, regulation, and physiological function of CTRP3. © 2017 American Physiological Society. Compr Physiol 7:863-878, 2017.
摘要
作为最大的内分泌器官，脂肪组织分泌许多在血液中循环的生物活性分子，统称为脂肪因子。鉴定此类代谢调节因子的努力导致了一个分泌蛋白家族的发现，该家族被命名为C1q肿瘤坏死因子（TNF）相关蛋白（CTRP）。CTRP蛋白、脂联素、TNF-α以及其他具有独特C1q结构域的蛋白被统称为C1q/TNF超家族。这些源自脂肪组织的CTRP因子的初步特征显示出对多种组织类型的代谢、炎症和生存信号具有广泛影响，这反映了其强大的生物学效能。CTRP3（也称为CORS26、cartducin或cartonectin）是这个脂肪因子家族的一个独特成员。在本综述中，我们全面概述了有关CTRP3的表达、调节和生理功能的研究。©2017美国生理学会。综合生理学7:863 - 878，2017。
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C1q/Tumor Necrosis Factor-Related Protein-3 Attenuates Brain Injury after Intracerebral Hemorrhage via AMPK-Dependent Pathway in Rat.C1q/肿瘤坏死因子相关蛋白-3通过大鼠中的AMPK依赖性途径减轻脑出血后的脑损伤。
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