Niu Qingsheng, Zhu Ziyi, Jiang Yaowen, Wan Zhi
Department of Emergency Medicine, West China Hospital of Sichuan University, Sichuan University, Chengdu, China.
Laboratory of Emergency Medicine, Disaster Medical Center, West China Hospital of Sichuan University, Chengdu, China.
Front Neurosci. 2025 Jun 17;19:1582743. doi: 10.3389/fnins.2025.1582743. eCollection 2025.
C1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a novel adipokine that has been shown to exert neuroprotective effects in acute cerebral infarction. However, conflicting results have emerged regarding the circulating levels of CTRP3 between patients with acute ischemic stroke and healthy individuals. This meta-analysis aims to investigate the association between circulating CTRP3 levels and acute ischemic stroke.
The objective of this meta-analysis is to re-evaluate the relationship between circulating CTRP3 levels and acute ischemic stroke.
We conducted a comprehensive search across PubMed, Web of Science, Embase, Cochrane Library, CNKI, VIP, Wanfang Data, and CBM to identify relevant studies up to February 2025 and 110 articles were found. After screening the titles, abstracts, and full texts, a total of 14 articles were ultimately included in this meta-analysis. Due to high heterogeneity, we conducted subgroup analyses stratified by patient characteristics, clinical and biochemical parameters, carotid intima-media thickness, IL-6 levels, CTRP9 levels, smoking, hypertension, and diabetes. Publication bias was evaluated using Egger's regression test, Begg's correlation analysis, and funnel plot visualizations.
The results indicated that patients with acute ischemic stroke exhibited significantly lower circulating levels of CTRP3 compared with control group ( = 6.04, < 0.00001). Subgroup analysis revealed that the observed heterogeneity could be attributed to patient age and body mass index (BMI). The year of publication, clinical biochemical parameters, carotid intima-media thickness, IL-6, CTRP9, smoking, hypertension, and diabetes categorization were not sources of heterogeneity.
The meta-analysis confirmed that circulating levels of CTRP3 were significantly lower in patients with acute ischemic stroke compared with control group. This association may be modulated by patient age and BMI.
C1q肿瘤坏死因子（TNF）相关蛋白3（CTRP3）是一种新型脂肪因子，已被证明在急性脑梗死中发挥神经保护作用。然而，急性缺血性脑卒中患者与健康个体之间CTRP3的循环水平出现了相互矛盾的结果。本荟萃分析旨在研究循环CTRP3水平与急性缺血性脑卒中之间的关联。
本荟萃分析的目的是重新评估循环CTRP3水平与急性缺血性脑卒中之间的关系。
我们对PubMed、Web of Science、Embase、Cochrane图书馆、中国知网、维普资讯、万方数据和中国生物医学文献数据库进行了全面检索，以识别截至2025年2月的相关研究，共找到110篇文章。在筛选标题、摘要和全文后，本荟萃分析最终纳入了14篇文章。由于异质性较高，我们按患者特征、临床和生化参数、颈动脉内膜中层厚度、白细胞介素-6水平、CTRP9水平、吸烟、高血压和糖尿病进行了亚组分析。使用Egger回归检验、Begg相关性分析和漏斗图可视化评估发表偏倚。
结果表明，与对照组相比，急性缺血性脑卒中患者的循环CTRP3水平显著降低（ = 6.04， < 0.00001）。亚组分析显示，观察到的异质性可能归因于患者年龄和体重指数（BMI）。发表年份、临床生化参数、颈动脉内膜中层厚度、白细胞介素-6、CTRP9、吸烟、高血压和糖尿病分类不是异质性来源。
荟萃分析证实，与对照组相比，急性缺血性脑卒中患者的循环CTRP3水平显著降低。这种关联可能受患者年龄和BMI的调节。
