John H. Sampson, Duke University, Durham, NC; Marcela V. Maus, Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Carl H. June, University of Pennsylvania, Philadelphia, PA.
J Clin Oncol. 2017 Jul 20;35(21):2450-2456. doi: 10.1200/JCO.2017.72.8089. Epub 2017 Jun 22.
Glioblastoma (GBM) is the most lethal form of brain tumor and remains a large, unmet medical need. This review focuses on recent advances in the neurosciences that converge with the broader field of immuno-oncology. Recent findings in neuroanatomy provide a basis for new approaches of cellular therapies for tumors that involve the CNS. The ultimate success of immunotherapy in the CNS will require improved imaging technologies and methods for analysis of the tumor microenvironment in patients with GBM. It is likely that combinatorial approaches with targeted immunotherapies will be required to exploit the vulnerabilities of GBM and other brain tumors.
胶质母细胞瘤（GBM）是最致命的脑肿瘤形式，仍然是一个巨大的、未满足的医疗需求。本综述重点介绍了神经科学的最新进展，这些进展与免疫肿瘤学的更广泛领域相融合。神经解剖学的最新发现为涉及中枢神经系统的肿瘤细胞治疗的新方法提供了基础。免疫疗法在中枢神经系统的最终成功将需要改进成像技术和方法，以分析 GBM 患者的肿瘤微环境。很可能需要联合靶向免疫疗法来利用 GBM 和其他脑肿瘤的脆弱性。
