Wang Xin, Kong Yujie, Chen Xi, Weng Zhanping, Li Baolai
Department of Obstetrics, Qingdao Municipal Hospital, Affiliated to Qingdao University, Medical College, Qingdao, China.
School of Health, Brooks College (Sunnyvale), Sunnyvale, CA, USA.
J Obstet Gynaecol. 2023 Dec;43(1):2171782. doi: 10.1080/01443615.2023.2171782.
The aetiological mechanism of preeclampsia (PE) is unclear exactly, so we attempted to investigate the association between susceptibility to preeclampsia and renin-angiotensin-aldosterone system (RAAS) gene polymorphisms to explore the aetiology in terms of genetics. A systematic search was performed in electronic databases to identify relevant studies. Eventually 73 studies were enrolled, odds ratios were generated by 5 genetic models. In overall analysis, significant associations were detected for AGT M235T, AT1R A1166C and CYP11B2 C344T whereas negative correlation was shown for AGT T174M. As stratified by race and geography, AGT 235T allele and AT1R 1166C allele increased preeclampsia risk and AGT T174M was justified uncorrelated with preeclampsia. Our meta-analysis illustrated that AGT 235T allele and AT1R 1166C allele increased and CYP11B2 344T allele decreased preeclampsia risk while AGT T174M polymorphism did not change preeclampsia risk. Hence, pregnant women carrying high-risk genotypes need strengthened management to prevent and early identification of preeclampsia.
子痫前期（PE）的确切病因机制尚不清楚，因此我们试图研究子痫前期易感性与肾素-血管紧张素-醛固酮系统（RAAS）基因多态性之间的关联，从遗传学角度探索病因。我们在电子数据库中进行了系统检索以识别相关研究。最终纳入了73项研究，通过5种遗传模型生成比值比。在总体分析中，检测到AGT M235T、AT1R A1166C和CYP11B2 C344T存在显著关联，而AGT T174M显示出负相关。按种族和地理分层后，AGT 235T等位基因和AT1R 1166C等位基因增加了子痫前期风险，而AGT T174M与子痫前期无相关性得到证实。我们的荟萃分析表明，AGT 235T等位基因和AT1R 1166C等位基因增加了子痫前期风险，而CYP11B2 344T等位基因降低了子痫前期风险，而AGT T174M多态性并未改变子痫前期风险。因此，携带高危基因型的孕妇需要加强管理，以预防和早期识别子痫前期。
