Schönbach Etienne M, Chaikitmongkol Voraporn, Annam Rachel, McDonnell Emma C, Wolfson Yulia, Fletcher Emily, Scholl Hendrik P N
Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Ophthalmic Res. 2017;58(2):117-124. doi: 10.1159/000475996. Epub 2017 Jun 23.
We present the multifocal electroretinogram (mfERG) with a 7-hexagon array as an objective test of macular function that can be recorded in 14 s. We provide normal values and investigate its reproducibility and validity.
Healthy participants underwent mfERG testing according to International Society for Clinical Electrophysiology of Vision (ISCEV) standards using the Espion Profile/D310 multifocal ERG system (Diagnosys, LLC, Lowell, MA, USA). One standard recording of a 61-hexagon array and 2 repeated recordings of a custom 7-hexagon array were obtained.
A total of 13 subjects (mean age 46.9 years) were included. The median response densities were 12.5 nV/deg2 in the center and 5.2 nV/deg2 in the periphery. Intereye correlations were strong in both the center (ρCenter = 0.821; p < 0.0001) and the periphery (ρPeriphery = 0.862; p < 0.0001). Intraeye correlations were even stronger: ρCenter = 0.904 with p < 0.0001 and ρPeriphery = 0.955 with p < 0.0001. Bland-Altman plots demonstrated an acceptable retest mean difference in both the center and periphery, and narrow limits of agreement. We found strong correlations of the center (ρCenter = 0.826; p < 0.0001) and periphery (ρPeriphery = 0.848; p < 0.0001), with recordings obtained by the 61-hexagon method.
The 7-hexagon mfERG provides reproducible results in agreement with results obtained according to the ISCEV standard.
我们介绍一种采用7六边形阵列的多焦视网膜电图（mfERG），作为一种可在14秒内记录的黄斑功能客观检测方法。我们提供了正常值，并研究了其可重复性和有效性。
健康参与者根据国际临床视觉电生理学会（ISCEV）标准，使用Espion Profile/D310多焦视网膜电图系统（美国马萨诸塞州洛厄尔市Diagnosys有限责任公司）进行mfERG检测。获得了一次61六边形阵列的标准记录和两次定制7六边形阵列的重复记录。
共纳入13名受试者（平均年龄46.9岁）。中心区域的中位数反应密度为12.5 nV/deg²，周边区域为5.2 nV/deg²。双眼中心区域（ρ中心 = 0.821；p < 0.0001）和周边区域（ρ周边 = 0.862；p < 0.0001）的相关性都很强。眼内相关性更强：ρ中心 = 0.904，p < 0.0001；ρ周边 = 0.955，p < 0.0001。Bland-Altman图显示中心和周边的重测平均差异均可接受，且一致性界限较窄。我们发现中心区域（ρ中心 = 0.826；p < 0.0001）和周边区域（ρ周边 = 0.848；p < 0.0001）与61六边形方法获得的记录有很强的相关性。
7六边形mfERG提供了可重复的结果，与根据ISCEV标准获得的结果一致。
