SCH-23390对D-2多巴胺激动剂的拮抗作用取决于儿茶酚胺能神经元。
SCH-23390 antagonism of a D-2 dopamine agonist depends upon catecholaminergic neurons.
作者信息
Breese G R, Mueller R A
出版信息
Eur J Pharmacol. 1985 Jul 11;113(1):109-14. doi: 10.1016/0014-2999(85)90349-8.
Abstract
SCH-23390, a selective D-1 dopamine antagonist, was found to antagonize the locomotor stimulation induced by LY-171555, an action similar to that for haloperidol in control animals. However, this action of SCH-23390 was prevented in rats treated with 6-hydroxydopamine (6-OHDA) or with reserpine plus alpha-methyl-tyrosine pretreatment. These results indicate that the action of SCH-23390 to antagonize D-2 dopamine receptor actions is dependent upon functional catecholamine-containing neurons. In contrast to the lack of action of SCH-23390 to antagonize LY-171555 in 6-OHDA-treated rats, SCH-23390 blocked the locomotor stimulation induced by SKF-39393, a D-1 dopamine agonist, after this treatment. Thus, D-1 dopamine receptors are distinct from D-2 receptor sites and can exhibit a behavior similar to that observed when D-2 receptors are stimulated. These data suggest that D-1 receptor sites modulate D-2 dopamine receptor function through a mechanism dependent upon functionally intact catecholamine-containing neurons.
摘要
SCH-23390是一种选择性D-1多巴胺拮抗剂，研究发现它能拮抗LY-171555诱导的运动兴奋，这一作用与对照动物中氟哌啶醇的作用相似。然而，在用6-羟基多巴胺（6-OHDA）处理或用利血平加α-甲基酪氨酸预处理的大鼠中，SCH-23390的这一作用受到了抑制。这些结果表明，SCH-23390拮抗D-2多巴胺受体作用的行为依赖于含功能正常的儿茶酚胺能神经元。与SCH-23390在6-OHDA处理的大鼠中对LY-171555缺乏拮抗作用相反，在该处理后，SCH-23390能阻断D-1多巴胺激动剂SKF-39393诱导的运动兴奋。因此，D-1多巴胺受体与D-2受体位点不同，并且能表现出与刺激D-2受体时观察到的行为相似的行为。这些数据表明，D-1受体位点通过一种依赖于功能完整的含儿茶酚胺能神经元的机制来调节D-2多巴胺受体功能。
相似文献
1
SCH-23390 antagonism of a D-2 dopamine agonist depends upon catecholaminergic neurons.SCH-23390对D-2多巴胺激动剂的拮抗作用取决于儿茶酚胺能神经元。
Eur J Pharmacol. 1985 Jul 11;113(1):109-14. doi: 10.1016/0014-2999(85)90349-8.
2
3
6-hydroxydopamine treatments enhance behavioral responses to intracerebral microinjection of D1- and D2-dopamine agonists into nucleus accumbens and striatum without changing dopamine antagonist binding.6-羟基多巴胺处理增强了对向伏隔核和纹状体内脑微量注射D1和D2多巴胺激动剂的行为反应，而不改变多巴胺拮抗剂结合。
J Pharmacol Exp Ther. 1987 Jan;240(1):167-76.
4
Lesions of the nigrostriatal dopamine projection increase the inhibitory effects of D1 and D2 dopamine agonists on caudate-putamen neurons and relieve D2 receptors from the necessity of D1 receptor stimulation.黑质纹状体多巴胺投射的损伤增加了D1和D2多巴胺激动剂对尾状核-壳核神经元的抑制作用，并使D2受体无需D1受体刺激。
J Neurosci. 1990 Jul;10(7):2318-29. doi: 10.1523/JNEUROSCI.10-07-02318.1990.
5
6
Why does clozapine stimulate the motor activity of reserpine-pretreated rats when combined with a dopamine D1 receptor agonist?当与多巴胺 D1 受体激动剂联合使用时，氯氮平为何会刺激经利血平预处理的大鼠的运动活性？
Eur J Pharmacol. 1995 Aug 25;282(1-3):137-44. doi: 10.1016/0014-2999(95)00308-8.
7
Different roles of D-1 and D-2 dopamine receptors involved in locomotor activity of supersensitive mice.D-1和D-2多巴胺受体在超敏小鼠运动活动中的不同作用。
Eur J Pharmacol. 1988 Apr 13;148(3):419-26. doi: 10.1016/0014-2999(88)90121-5.
8
Differential effects of dopamine agonists on locomotion in intact and reserpine-treated mice.多巴胺激动剂对完整小鼠和利血平处理小鼠运动的不同影响。
Gen Pharmacol. 1991;22(6):1027-31. doi: 10.1016/0306-3623(91)90573-o.
9
Behavioural stimulation is induced by separate dopamine D-1 and D-2 receptor sites in reserpine-pretreated but not in normal rats.行为刺激是由利血平预处理大鼠中不同的多巴胺D-1和D-2受体位点诱导产生的，而正常大鼠中则不然。
Eur J Pharmacol. 1985 Jul 11;113(1):79-88. doi: 10.1016/0014-2999(85)90345-0.
10
Enhancement by a single dose of reserpine (plus alpha methyl-p-tyrosine) of the central stimulatory effects evoked by dopamine D-1 and D-2 agonists in the mouse.单剂量利血平（加α-甲基-对-酪氨酸）增强多巴胺D-1和D-2激动剂在小鼠中诱发的中枢刺激作用。
Naunyn Schmiedebergs Arch Pharmacol. 1988 May;337(5):512-8. doi: 10.1007/BF00182724.
引用本文的文献
1
Neonatal 6-hydroxydopamine lesioning of rats and dopaminergic neurotoxicity: proposed animal model of Parkinson's disease.大鼠新生期 6-羟多巴胺损毁与多巴胺能神经毒性：帕金森病拟似动物模型。
J Neural Transm (Vienna). 2022 Jun;129(5-6):445-461. doi: 10.1007/s00702-022-02479-4. Epub 2022 Mar 12.
2
All-Atom Molecular Dynamics Investigations on the Interactions between D2 Subunit Dopamine Receptors and Three C-Labeled Radiopharmaceutical Ligands.全原子分子动力学研究 D2 亚单位多巴胺受体与三种 C 标记放射性配体的相互作用。
Int J Mol Sci. 2022 Feb 11;23(4):2005. doi: 10.3390/ijms23042005.
3
Behavioural supersensitivity following neonatal 6-hydroxydopamine: attenuation by MK-801.新生期6-羟基多巴胺诱导的行为超敏反应：MK-801的抑制作用
Neurotox Res. 2007 Sep;12(2):113-24. doi: 10.1007/BF03033920.
4
Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients.Cadps2基因敲除小鼠的自闭症样表型及自闭症患者中CADPS2的异常剪接
J Clin Invest. 2007 Apr;117(4):931-43. doi: 10.1172/JCI29031. Epub 2007 Mar 22.
5
The adenosine receptor antagonist theophylline induces a monoamine-dependent increase of the anticataleptic effects of NMDA receptor antagonists.
Naunyn Schmiedebergs Arch Pharmacol. 1996 Jul;354(2):179-86. doi: 10.1007/BF00178718.
6
Selective dopamine antagonist pretreatment on the antiparkinsonian effects of benzazepine D1 dopamine agonists in rodent and primate models of Parkinson's disease--the differential effects of D1 dopamine antagonists in the primate.在帕金森病啮齿动物和灵长类动物模型中，选择性多巴胺拮抗剂预处理对苯并氮杂卓类D1多巴胺激动剂抗帕金森病作用的影响——D1多巴胺拮抗剂在灵长类动物中的差异效应
Psychopharmacology (Berl). 1995 Feb;117(4):403-12. doi: 10.1007/BF02246211.
7
6-hydroxydopamine treatments enhance behavioral responses to intracerebral microinjection of D1- and D2-dopamine agonists into nucleus accumbens and striatum without changing dopamine antagonist binding.6-羟基多巴胺处理增强了对向伏隔核和纹状体内脑微量注射D1和D2多巴胺激动剂的行为反应，而不改变多巴胺拮抗剂结合。
J Pharmacol Exp Ther. 1987 Jan;240(1):167-76.
8
Antagonism of apomorphine-induced yawning by SCH 23390: evidence against the autoreceptor hypothesis.SCH 23390对阿扑吗啡诱发呵欠的拮抗作用：反对自身受体假说的证据
Psychopharmacology (Berl). 1986;89(2):259-60. doi: 10.1007/BF00310640.
9
Bromocriptine-induced locomotor stimulation in mice is modulated by dopamine D-1 receptors.溴隐亭对小鼠运动的刺激作用受多巴胺D-1受体调节。
J Neural Transm. 1987;69(1-2):131-45. doi: 10.1007/BF01244104.
10
Inhibition of SKF 38393- and pergolide-induced circling in rats with unilateral 6-OHDA lesion is correlated to dopamine D-1 and D-2 receptor affinities in vitro.用单侧6-羟基多巴胺损伤的大鼠中，SKF 38393和培高利特诱导的旋转行为的抑制与体外多巴胺D-1和D-2受体亲和力相关。
J Neural Transm. 1986;67(3-4):225-40. doi: 10.1007/BF01243350.
本文引用的文献
1
Simultaneous quantification of dopamine, 5-hydroxytryptamine and four metabolically related compounds by means of reversed-phase high-performance liquid chromatography with electrochemical detection.采用反相高效液相色谱-电化学检测法同时定量测定多巴胺、5-羟色胺及四种代谢相关化合物。
J Chromatogr. 1981 Oct 9;225(2):347-57. doi: 10.1016/s0378-4347(00)80283-2.
2
Evidence that LY-141865 specifically stimulates the D-2 dopamine receptor.LY-141865特异性刺激D-2多巴胺受体的证据。
Nature. 1981 Jul 30;292(5822):463-5. doi: 10.1038/292463a0.
3
Dopaminergic behaviour stereospecific promoted by the D1 agonist R-SK & F 38393 and selectively blocked by the D1 antagonist SCH 23390.D1激动剂R-SK & F 38393可立体特异性地促进多巴胺能行为，并被D1拮抗剂SCH 23390选择性阻断。
Psychopharmacology (Berl). 1984;82(4):409-10. doi: 10.1007/BF00427697.
4
Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum.大鼠纹状体中选择性D-1受体拮抗剂配体3H-SCH 23390的结合特性研究
Life Sci. 1984 Oct 29;35(18):1885-93. doi: 10.1016/0024-3205(84)90540-x.
5
SCH-23390: a selective D1 dopamine antagonist with potent D2 behavioral actions.
Eur J Pharmacol. 1984 May 18;101(1-2):159-60. doi: 10.1016/0014-2999(84)90044-x.
6
SCH 23390 - the first selective dopamine D-1 antagonist.SCH 23390——首个选择性多巴胺D-1拮抗剂。
Eur J Pharmacol. 1983 Jul 15;91(1):153-4. doi: 10.1016/0014-2999(83)90381-3.
7
8
Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions.多巴胺D-1和D-2拮抗剂对单侧6-羟基多巴胺损伤大鼠中多巴胺激动剂诱导的转圈行为的差异性抑制作用。
Eur J Pharmacol. 1984 Jul 13;102(2):349-54. doi: 10.1016/0014-2999(84)90267-x.
9
Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics.一种特定多巴胺D-1拮抗剂SCH 23390与抗精神病药物相比的药理作用。
Life Sci. 1984 Apr 16;34(16):1529-40. doi: 10.1016/0024-3205(84)90607-6.
10
SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems.SCH 23390，一种可能的苯并氮杂䓬类抗精神病药物，对多巴胺能系统具有独特的相互作用。
J Pharmacol Exp Ther. 1983 Aug;226(2):462-8.
Zotero 插件