Bondarenko N A, Bondarenko N A
Farmakol Toksikol. 1985 Jul-Aug;48(4):31-4.
Administration to rats of madopar in a dose of 125 mg/kg produced stereotypy, decrease in the exploration activity in the open field test, loss of the ability to decide the extrapolation problem (escape out of acute stressful situation). The latter type of behavioral pathology alone was selectively averted by administering the classical neuroleptics fluorophenazine, haloperidol and its analog azaperone. Atypical neuroleptics and the the antidepressant imipramine were less effective and reduced but animals' motor excitation induced by madopar according to the extrapolation avoidance test. The tranquilizer phenazepam did not influence behavioral pathology in this test. The data obtained suggest that impairment of the animals' behavioral pattern in the extrapolation avoidance test on madopar administration in a dose of 125 mg/kg may serve an experimental model for evaluating the neuroleptic effect of the drugs.
给大鼠注射125毫克/千克剂量的美多芭会产生刻板行为，在旷场试验中探索活动减少，丧失解决外推问题（从急性应激状态中逃脱）的能力。单独通过给予经典抗精神病药物氟奋乃静、氟哌啶醇及其类似物阿扎哌隆，可选择性避免后一种行为病理学类型。非典型抗精神病药物和抗抑郁药丙咪嗪效果较差，根据外推回避试验，它们可减轻美多芭诱导的动物运动兴奋。在该试验中，镇静剂苯氮䓬不影响行为病理学。所获得的数据表明，给予125毫克/千克剂量美多芭后，大鼠在外推回避试验中的行为模式受损，可作为评估药物抗精神病作用的实验模型。
