Svob Connie, Liu Jie, Wickramaratne Priya, Hao Xuejun, Talati Ardesheer, Kayser Jürgen, Tenke Craig, Warner Virginia, Yang Jie, Anderson Micheline, Weissman Myrna M
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA.
Spiritual Clin Pract (Wash D C ). 2017 Mar;4(1):32-42. doi: 10.1037/scp0000123.
To examine potential neural substrates that underlie the interplay between religiosity/spirituality and risk-for-depression. A new wave of data from a longitudinal, three generation study of individuals at high risk for depression is presented. In addition to providing new longitudinal data, we extend previous findings by employing additional (surface-based) methods for examining cortical volume.
Magnetic resonance imaging (MRI) scans were collected on 106 second and third generation family members at high or low risk for major depression defined by the presence or absence of depression in the first generation. Religiosity/spirituality measures were collected at the same time as the MRI scans and comprised self-report ratings of personal religious/spiritual (R/S) importance and frequency of religious attendance. Analyses were carried out with Freesurfer. Interactive effects of religiosity/spirituality and risk-for-depression were examined on measures of cortical thickness and cortical surface area.
A high degree of belief in the importance of religion/spirituality was associated with both a thicker cortex and a larger pial surface area in persons at high risk for familial depression. No significant association was found between cortical regions and religious attendance in either risk group.
The results support previous findings of an association between R/S importance and cortical thickness in individuals at high risk for depression, and extend the findings to include an association between R/S importance and greater pial surface area. Moreover, the findings suggest these cortical changes may confer protective benefits to religious/spiritual individuals at high risk for depression.
研究宗教信仰/精神性与抑郁风险之间相互作用的潜在神经基础。本文呈现了一项针对抑郁症高风险个体的纵向三代研究的新一波数据。除了提供新的纵向数据外，我们还通过采用额外的（基于表面的）方法来检查皮质体积，扩展了先前的研究结果。
对106名第二代和第三代家庭成员进行了磁共振成像（MRI）扫描，这些成员根据第一代是否患有抑郁症被界定为高或低抑郁症风险个体。宗教信仰/精神性测量与MRI扫描同时进行，包括个人宗教/精神（R/S）重要性的自我报告评分和宗教活动参与频率。使用FreeSurfer进行分析。研究了宗教信仰/精神性与抑郁风险的交互作用对皮质厚度和皮质表面积测量值的影响。
在家族性抑郁症高风险个体中，对宗教信仰/精神性重要性的高度信仰与更厚的皮质和更大的软脑膜表面积相关。在任何一个风险组中，均未发现皮质区域与宗教活动参与之间存在显著关联。
研究结果支持了先前关于抑郁症高风险个体中R/S重要性与皮质厚度之间存在关联的发现，并将这一发现扩展至包括R/S重要性与更大软脑膜表面积之间的关联。此外，研究结果表明，这些皮质变化可能对抑郁症高风险的宗教/精神性个体具有保护作用。
