Yang Shu-Mei, Reddy Ganapuram Madhusudhan, Wang Tzu-Ping, Yeh Yu-Sheng, Wang Min, Lin Wenwei
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China.
Chem Commun (Camb). 2017 Jul 4;53(54):7649-7652. doi: 10.1039/c7cc03995f.
A highly enantioselective cascade reaction for the generation of five quaternary stereocenters in one-pot operation is reported for the first time in the history of organic synthesis. Cinchona-alkaloid derived hydrogen-bonding catalyst furnished structurally complex cascade products from simple substrates in excellent yields and stereoselectivities.
