Buchan A M, Sikora L K, Levy J G, McIntosh C H, Dyck I, Brown J C
Histochemistry. 1985;83(2):175-80. doi: 10.1007/BF00495150.
Four monoclonal antibodies specific for somatostatin have been produced and characterized. These antibodies were used to assess the anatomical relationship of somatostatin-containing cells in the pancreas and gastrointestinal tract of man, baboon and rat with ten other peptide-containing endocrine cells. The peptides investigated were gastrin, cholecystokinin, motilin, secretin, neurotensin, gastric inhibitory polypeptide, gut-glucagon, pancreatic glucagon, pancreatic polypeptide and insulin. The only regions in which somatostatin cells were seen in close contact with another endocrine cell were in the pancreas and the gastric antrum. In the pancreas somatostatin cells were commonly seen in close contact with insulin, glucagon and pancreatic polypeptide cells and infrequent contact was demonstrable with the gastrin-immunoreactive cells in the antrum of both rat and man. In all other cases no evidence was obtained for a close anatomical relationship between somatostatin cells and the other enteroendocrine cells.
已制备并鉴定出四种对生长抑素具有特异性的单克隆抗体。这些抗体被用于评估人、狒狒和大鼠的胰腺及胃肠道中含生长抑素的细胞与其他十种含肽内分泌细胞之间的解剖学关系。所研究的肽包括胃泌素、胆囊收缩素、胃动素、促胰液素、神经降压素、胃抑制多肽、肠高血糖素、胰高血糖素、胰多肽和胰岛素。生长抑素细胞与另一种内分泌细胞紧密接触的唯一区域是在胰腺和胃窦。在胰腺中，生长抑素细胞常与胰岛素、胰高血糖素和胰多肽细胞紧密接触，在大鼠和人的胃窦中，与胃泌素免疫反应性细胞的接触较少。在所有其他情况下，均未获得生长抑素细胞与其他肠内分泌细胞之间存在紧密解剖学关系的证据。
