Kibel Aleksandar, Selthofer-Relatic Kristina, Drenjancevic Ines, Bacun Tatjana, Bosnjak Ivica, Kibel Dijana, Gros Mario
1 Department for Heart and Vascular Diseases, Clinic of Internal Medicine, Osijek University Hospital, Osijek, Croatia.
2 Department of Physiology and Immunology, Faculty of Medicine, University of Osijek, Croatia.
J Int Med Res. 2017 Dec;45(6):1901-1929. doi: 10.1177/0300060516675504. Epub 2017 Jan 12.
The significance, mechanisms and consequences of coronary microvascular dysfunction associated with diabetes mellitus are topics into which we have insufficient insight at this time. It is widely recognized that endothelial dysfunction that is caused by diabetes in various vascular beds contributes to a wide range of complications and exerts unfavorable effects on microcirculatory regulation. The coronary microcirculation is precisely regulated through a number of interconnected physiological processes with the purpose of matching local blood flow to myocardial metabolic demands. Dysregulation of this network might contribute to varying degrees of pathological consequences. This review discusses the most important findings regarding coronary microvascular dysfunction in diabetes from pre-clinical and clinical perspectives.
与糖尿病相关的冠状动脉微血管功能障碍的意义、机制及后果是目前我们认识不足的课题。人们普遍认识到，糖尿病在各种血管床中引起的内皮功能障碍会导致多种并发症，并对微循环调节产生不利影响。冠状动脉微循环通过一系列相互关联的生理过程进行精确调节，目的是使局部血流与心肌代谢需求相匹配。该网络的失调可能会导致不同程度的病理后果。本综述从临床前和临床角度讨论了有关糖尿病冠状动脉微血管功能障碍的最重要发现。
