Haghi Alireza Rastgoo, Vahedi Amir, Shekarchi Ali Akbar, Kamran Aziz
Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran.
Women Reproductive Health Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cancer Res Ther. 2017 Apr-Jun;13(2):257-261. doi: 10.4103/0973-1482.204894.
Breast cancer is the most common cancer among women. There are several prognostic factors for this disease. The aim of this article is to explore the correlation of serum level of vascular endothelial growth factor (VEGF) and intercellular adhesion molecule 1 (ICAM1) with tumor, node, metastasis staging and grading of breast cancer.
Serum samples of 51 patients with breast cancer were assessed with enzyme-linked immunosorbent assay for the level of VEGF and ICAM1 preoperatively. After the operation, histopathologic specimens stained with hematoxylin and eosin were evaluated for tumor size, histopathologic subtype, grade, lymph node, vascular and lymphatic involvement. Then, the correlation of tumor stage and grade and serum level of markers was analyzed.
There was no significant correlation between serum level of markers with vascular invasions, lymph node involvement, and menstruation. There was a weak correlation between tumor size and serum level of ICAM1 with Pearson score correlation, but there was no significant correlation with VEGF. There was no significant correlation between tumor grading and staging with the level of markers. There was a significant correlation between the level of VEGF and ICAM1 and histologic type of tumors in invasive through in situ tumors.
Levels of VEGF and ICAM1 can be used as a predictor of tumor invasion and also for target therapy.
乳腺癌是女性中最常见的癌症。该疾病存在多种预后因素。本文旨在探讨血管内皮生长因子（VEGF）和细胞间黏附分子1（ICAM1）的血清水平与乳腺癌的肿瘤、淋巴结、转移分期及分级之间的相关性。
采用酶联免疫吸附测定法对51例乳腺癌患者术前血清样本中的VEGF和ICAM1水平进行评估。术后，对苏木精和伊红染色的组织病理学标本进行评估，以确定肿瘤大小、组织病理学亚型、分级、淋巴结、血管及淋巴管受累情况。然后，分析肿瘤分期、分级与标志物血清水平之间的相关性。
标志物血清水平与血管侵犯、淋巴结受累及月经情况之间无显著相关性。肿瘤大小与ICAM1血清水平之间存在弱相关性（Pearson评分相关性），但与VEGF无显著相关性。肿瘤分级和分期与标志物水平之间无显著相关性。在浸润性肿瘤与原位肿瘤中，VEGF和ICAM1水平与肿瘤组织学类型之间存在显著相关性。
VEGF和ICAM1水平可作为肿瘤侵袭的预测指标，也可用于靶向治疗。
