College of Pharmaceutical Science & Green Pharmaceutical Collaborative Innovation Center of Yangtze River Delta Region, Zhejiang University of Technology , Hangzhou, 310014, P. R. China.
Org Lett. 2017 Jul 7;19(13):3418-3421. doi: 10.1021/acs.orglett.7b01374. Epub 2017 Jun 23.
A simple and efficient method was developed for the construction of the medicinally important tetracyclic 3-spirooxindole benzofuranones. In this highly atom- and step-economical one-pot protocol, one quaternary carbon center, two new cycles, and four new bonds (C-C/C-O/C-N) were formed under simple ligand-free copper-catalyzed conditions through a novel tandem oxidative annulation strategy.
本文发展了一种简洁高效的方法，用于构建具有重要药用价值的四环 3-螺氧化吲哚苯并呋喃酮。在这个高度原子经济性和步骤经济性的一锅法中，在简单的无配体铜催化条件下，通过新颖的串联氧化环合策略，仅需一个季碳中心、两个新环和四个新键（C-C/C-O/C-N）即可形成。
