School of Chemistry & Environmental Engineering, International Healthcare Innovation Institute, Wuyi University , Jiangmen 529020, China.
Org Lett. 2018 Jan 5;20(1):220-223. doi: 10.1021/acs.orglett.7b03580. Epub 2017 Dec 8.
An efficient and environmentally benign Cu-mediated method was developed for direct cascade C-H/N-H annulation to construct polyheterocyclic indoloquinoline scaffolds. This method highlights an emerging strategy for transforming inert C-H bonds into versatile functional groups in organic synthesis and provides a new versatile approach for the efficient synthesis of indolo[3,2-c] and [2,3-c]quinoline alkaloids.
发展了一种高效、环境友好的 Cu 介导方法，用于直接级联 C-H/N-H 环化构建多杂环吲哚喹啉骨架。该方法为在有机合成中转化惰性 C-H 键为多功能基团提供了一种新的策略，并为高效合成吲哚[3,2-c]和[2,3-c]喹啉生物碱提供了一种新的通用方法。
