运动对实体瘤患儿免疫功能的影响：来自PAPEC随机试验的见解
Effects of Exercise on the Immune Function of Pediatric Patients With Solid Tumors: Insights From the PAPEC Randomized Trial.
作者信息
Fiuza-Luces Carmen, Padilla Julio R, Valentín Jaime, Santana-Sosa Elena, Santos-Lozano Alejandro, Sanchis-Gomar Fabián, Pareja-Galeano Helios, Morales Javier S, Fleck Steven J, Pérez Margarita, Lassaletta Alvaro, Soares-Miranda Luisa, Pérez-Martínez Antonio, Lucia Alejandro
机构信息
From the Research Institute of the Hospital '12 de Octubre' (i+12), Madrid, Spain (CF-L, ES-S, AS-L, FS-G, HP-G, A. Lucia); Spanish Network for Biomedical Research in Rare Diseases (CIBERER), U723, Spain (CF-L); European University, Madrid, Spain (JRP, ES-S, HP-G, JSM, MP, A. Lucia); Innate Immune Research Group, IdiPAZ, Madrid, Spain (JV); i+HeALTH Department of Health Sciences, European University Miguel de Cervantes, Valladolid, Spain (AS-L); Department of Physiology, Faculty of Medicine, University of Valencia and Fundación de Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain (FS-G); Andrews Research and Education Foundation, Gulf Breeze, Florida (SJF); Department of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital Niño Jesús, Madrid, Spain (A. Lassaletta); Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal (LS-M); and Department of Pediatric Hemato-Oncology and Stem Cell Transplantation, University Hospital La Paz, Madrid, Spain (AP-M).
出版信息
Am J Phys Med Rehabil. 2017 Nov;96(11):831-837. doi: 10.1097/PHM.0000000000000757.
The purpose of this study was to assess the effects of an in-hospital exercise intervention during neoadjuvant chemotherapy on the inflammatory profile and immune cell subpopulation in 20 children with solid tumors (control [n = 11] and exercise group [n = 9]). Although no significant interaction (group × time) effect was found with an analysis of variance test, we found a trend toward an interaction effect for natural killer cells expressing the immunoglobulin-like receptor KIR2DS4, with their numbers remaining stable in the exercise group but increasing in controls. Our data support that exercise interventions are safe in pediatric cancer patients with solid tumors during chemotherapy treatment despite its aggressive, immunosuppressive nature.
本研究旨在评估新辅助化疗期间住院运动干预对20名实体瘤儿童（对照组[n = 11]和运动组[n = 9]）炎症指标和免疫细胞亚群的影响。虽然方差分析未发现显著的交互作用（组×时间）效应，但我们发现表达免疫球蛋白样受体KIR2DS4的自然杀伤细胞存在交互作用效应趋势，运动组中其数量保持稳定，而对照组中则增加。我们的数据支持，尽管化疗具有侵袭性和免疫抑制性，但运动干预对化疗期间患有实体瘤的儿科癌症患者是安全的。
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